LGMN - Legumain - human protein (Function)
 
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Protein
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References

 
LGMN »  Legumain   [ EC 3.4.22.34 ]
 
Protein also known as:  Asparaginyl endopeptidase.
Gene name:  LGMN
Family name: Peptidase C13
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.  
1
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • ISSUniProtKB
  • ISSOrtholog Curator
Peptidase activitydefinition[GO:0008233]  
1
  • IDAMGI
GO biological process 
Negative regulation of ERBB signaling pathwaydefinition[GO:1901185]  
  • ISSOrtholog Curator
Negative regulation of multicellular organism growthdefinition[GO:0040015] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • IGIMGI
Proteolysisdefinition[GO:0006508]  
1
  • ISSUniProtKB
  • ISSOrtholog Curator
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
  • ISSOrtholog Curator
Receptor catabolic processdefinition[GO:0032801]  
  • ISSOrtholog Curator
Renal system processdefinition[GO:0003014]  
  • ISSOrtholog Curator
Response to aciddefinition[GO:0001101] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.34: Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+5641  
Lysosome  hsa04142+5641  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Metabolism  REACT_111217  
Steroid hormones  REACT_15493  
 

Biophysicochemical properties

Dependence
pH Optimum pH is 5.5 for the free enzyme, and pH 6 in the presence of bound integrins.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q99538
Other
GeneWiki: LGMN
GenomeRNAi: 5641
PRO: PR:Q99538