MAP3K14 - Mitogen-activated protein kinase kinase kinase 14 - human protein (Function)
 
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MAP3K14 »  Mitogen-activated protein kinase kinase kinase 14   [ EC 2.7.11.25 ]
 
Protein also known as:  Serine/threonine-protein kinase NIK.
Gene name:  MAP3K14
Entry whose protein(s) existence is based on evidence at protein level
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1 61 1
GENE REF ISO

Function

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Overview 
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
MAP kinase kinase kinase activitydefinition[GO:0004709]  
  • IEAEC 2 GO
NF-kappaB-inducing kinase activitydefinition[GO:0004704]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
1
  • IDAMGI
GO biological process 
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
I-kappaB kinase/NF-kappaB signalingdefinition[GO:0007249]  
  • ISSOrtholog Curator
Immune responsedefinition[GO:0006955]  
  • ISSOrtholog Curator
NIK/NF-kappaB signalingdefinition[GO:0038061]  
  • ISSOrtholog Curator
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
2
  • RCAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+9020  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+9020  
HTLV-I infection  hsa05166+9020  
Intestinal immune network for IgA production  hsa04672+9020  
MAPK signaling pathway  hsa04010+9020  
Osteoclast differentiation  hsa04380+9020  
T cell receptor signaling pathway  hsa04660+9020  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP3K14
GenomeRNAi: 9020
PRO: PR:Q99558
Chemistry
GuidetoPHARMACOLOGY: 2074