P2RX7 - P2X purinoceptor 7 - human protein (Function)
 
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P2RX7 »  P2X purinoceptor 7  (P2X7)
 
Protein also known as:  Purinergic receptor.
Gene name:  P2RX7
Family name: P2X receptor
Entry whose protein(s) existence is based on evidence at protein level
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1 32 8
GENE REF ISO

Function

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Overview 
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-gated p2x receptor cation channel (p2x receptor) family  1.A.7.1.3  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • ICBHF-UCL
Extracellular ATP-gated cation channel activitydefinition[GO:0004931]  
1
  • IDABHF-UCL
Lipopolysaccharide bindingdefinition[GO:0001530]  
  • ISSOrtholog Curator
Protein homodimerization activitydefinition[GO:0042803]  
1
  • NASBHF-UCL
Purinergic nucleotide receptor activitydefinition[GO:0001614]  
1
  • IDABHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • ISSBHF-UCL
GO biological process 
Apoptotic signaling pathwaydefinition[GO:0097190]  
  • ISSOrtholog Curator
Bleb assemblydefinition[GO:0032060]  
  • ISSOrtholog Curator
Cation transportdefinition[GO:0006812]  
1
  • IDAGOC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
  • ISSOrtholog Curator
Membrane depolarizationdefinition[GO:0051899]  
1
  • IDABHF-UCL
Negative regulation of bone resorptiondefinition[GO:0045779]  
  • ISSOrtholog Curator
Negative regulation of MAPK cascadedefinition[GO:0043409]  
  • ISSOrtholog Curator
Pore complex assemblydefinition[GO:0046931]  
1
  • IDABHF-UCL
Positive regulation of bone mineralizationdefinition[GO:0030501]  
  • ISSOrtholog Curator
Positive regulation of calcium ion transport into cytosoldefinition[GO:0010524]  
1
  • IDABHF-UCL
Positive regulation of cytolysisdefinition[GO:0045919]  
  • ISSOrtholog Curator
Positive regulation of cytoskeleton organizationdefinition[GO:0051495]  
  • ISSOrtholog Curator
Positive regulation of interleukin-1 beta secretiondefinition[GO:0050718]  
2
  • IDABHF-UCL
Purinergic nucleotide receptor signaling pathwaydefinition[GO:0035590]  
1
  • IDAGOC
Regulation of killing of cells of other organismdefinition[GO:0051709]  
1
  • NASBHF-UCL
Regulation of sodium ion transportdefinition[GO:0002028]  
1
  • ISSBHF-UCL
Response to ATPdefinition[GO:0033198]  
1
  • IDABHF-UCL
Sensory perception of paindefinition[GO:0019233]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: P2RX7
GenomeRNAi: 5027
PRO: PR:Q99572
Chemistry
GuidetoPHARMACOLOGY: 484