P2RX7 - P2X purinoceptor 7 - human protein (Function)
 
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P2RX7 »  P2X purinoceptor 7  (P2X7)
 
Protein also known as:  Purinergic receptor.
Gene name:  P2RX7
Family name: P2X receptor
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-gated p2x receptor cation channel (p2x receptor) family  1.A.7.1.3  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • ICBHF-UCL
Copper ion bindingdefinition[GO:0005507] silver  
  • IEAOrtholog Compara
Extracellular ATP-gated cation channel activitydefinition[GO:0004931]  
1
  • IDABHF-UCL
Lipopolysaccharide bindingdefinition[GO:0001530]  
  • ISSOrtholog Curator
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • NASBHF-UCL
Purinergic nucleotide receptor activitydefinition[GO:0001614]  
1
  • IDABHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • ISSBHF-UCL
Scaffold protein bindingdefinition[GO:0097110] silver  
  • IEAOrtholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
  • IEAOrtholog Compara
Apoptotic signaling pathwaydefinition[GO:0097190]  
  • ISSOrtholog Curator
Bleb assemblydefinition[GO:0032060]  
  • ISSOrtholog Curator
Cell morphogenesisdefinition[GO:0000902] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
  • ISSOrtholog Curator
Cell volume homeostasisdefinition[GO:0006884] silver  
  • IEAOrtholog Compara
Cellular response to extracellular stimulusdefinition[GO:0031668] silver  
  • IEAOrtholog Compara
Ceramide biosynthetic processdefinition[GO:0046513] silver  
  • IEAOrtholog Compara
Collagen metabolic processdefinition[GO:0032963] silver  
  • IEAOrtholog Compara
Cytolysisdefinition[GO:0019835] silver  
  • IEAOrtholog Compara
Defense response to Gram-positive bacteriumdefinition[GO:0050830] silver  
  • IEAOrtholog Compara
Homeostasis of number of cells within a tissuedefinition[GO:0048873] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Ion transmembrane transportdefinition[GO:0034220]  
1
  • IDAGOC
Membrane buddingdefinition[GO:0006900] silver  
  • IEAOrtholog Compara
Membrane depolarizationdefinition[GO:0051899]  
1
  • IDABHF-UCL
Membrane protein ectodomain proteolysisdefinition[GO:0006509] silver  
  • IEAOrtholog Compara
Mitochondrion organizationdefinition[GO:0007005] silver  
  • IEAOrtholog Compara
Multicellular organismal protein catabolic processdefinition[GO:0044254] silver  
  • IEAOrtholog Compara
NAD transportdefinition[GO:0043132] silver  
  • IEAOrtholog Compara
Negative regulation of bone resorptiondefinition[GO:0045779]  
  • ISSOrtholog Curator
Negative regulation of MAPK cascadedefinition[GO:0043409]  
  • ISSOrtholog Curator
Neuronal action potentialdefinition[GO:0019228] silver  
  • IEAOrtholog Compara
Phagolysosome assemblydefinition[GO:0001845] silver  
  • IEAOrtholog Compara
Phospholipid transfer to membranedefinition[GO:0006649] silver  
  • IEAOrtholog Compara
Phospholipid translocationdefinition[GO:0045332] silver  
  • IEAOrtholog Compara
Plasma membrane organizationdefinition[GO:0007009] silver  
  • IEAOrtholog Compara
Pore complex assemblydefinition[GO:0046931]  
1
  • IDABHF-UCL
Positive regulation of bone mineralizationdefinition[GO:0030501]  
  • ISSOrtholog Curator
Positive regulation of calcium ion transport into cytosoldefinition[GO:0010524]  
1
  • IDABHF-UCL
Positive regulation of cytolysisdefinition[GO:0045919]  
  • ISSOrtholog Curator
Positive regulation of cytoskeleton organizationdefinition[GO:0051495]  
  • ISSOrtholog Curator
Positive regulation of gamma-aminobutyric acid secretiondefinition[GO:0014054] silver  
  • IEAOrtholog Compara
Positive regulation of glutamate secretiondefinition[GO:0014049] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-1 alpha secretiondefinition[GO:0050717] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-1 beta secretiondefinition[GO:0050718]  
2
  • IDABHF-UCL
Positive regulation of interleukin-6 productiondefinition[GO:0032755] silver  
  • IEAOrtholog Compara
Positive regulation of lymphocyte apoptotic processdefinition[GO:0070230] silver  
  • IEAOrtholog Compara
Positive regulation of mitochondrial depolarizationdefinition[GO:0051901] silver  
  • IEAOrtholog Compara
Positive regulation of prostaglandin secretiondefinition[GO:0032308] silver  
  • IEAOrtholog Compara
Positive regulation of T cell mediated cytotoxicitydefinition[GO:0001916] silver  
  • IEAOrtholog Compara
Protein oligomerizationdefinition[GO:0051259] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAOrtholog Compara
Protein processingdefinition[GO:0016485] silver  
  • IEAOrtholog Compara
Reactive oxygen species metabolic processdefinition[GO:0072593] silver  
  • IEAOrtholog Compara
Regulation of killing of cells of other organismdefinition[GO:0051709]  
1
  • NASBHF-UCL
Regulation of sodium ion transportdefinition[GO:0002028]  
1
  • ISSBHF-UCL
Release of sequestered calcium ion into cytosoldefinition[GO:0051209] silver  
  • IEAOrtholog Compara
Response to ATPdefinition[GO:0033198]  
1
  • IDABHF-UCL
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
  • IEAOrtholog Compara
Response to fluid shear stressdefinition[GO:0034405] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to zinc iondefinition[GO:0010043] silver  
  • IEAOrtholog Compara
Sensory perception of paindefinition[GO:0019233]  
  • ISSOrtholog Curator
Skeletal system morphogenesisdefinition[GO:0048705] silver  
  • IEAOrtholog Compara
Synaptic vesicle exocytosisdefinition[GO:0016079] silver  
  • IEAOrtholog Compara
T cell homeostasisdefinition[GO:0043029] silver  
  • IEAOrtholog Compara
T cell proliferationdefinition[GO:0042098] silver  
  • IEAOrtholog Compara
Transmembrane transportdefinition[GO:0055085]  
1
  • IDAGOC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: P2RX7
GenomeRNAi: 5027
PRO: PR:Q99572
Chemistry
GuidetoPHARMACOLOGY: 484