SERPINI1 - Neuroserpin - human protein (Function)
 
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SERPINI1 »  Neuroserpin
 
Protein also known as:  Peptidase inhibitor 12 (PI-12).
Gene name:  SERPINI1
Family name: Serpin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.  
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867] silver  
  • IBARefGenome
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Central nervous system developmentdefinition[GO:0007417]  
1
  • TASPINC
Negative regulation of endopeptidase activitydefinition[GO:0010951] silver  
  • IBARefGenome
Peripheral nervous system developmentdefinition[GO:0007422]  
1
  • TASPINC
Regulation of cell adhesiondefinition[GO:0030155] silver  
  • IEAOrtholog Compara
Regulation of proteolysisdefinition[GO:0030162] silver  
  • IBARefGenome
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SERPINI1
GenomeRNAi: 5274
PRO: PR:Q99574