TBX5 - T-box transcription factor TBX5 - human protein (Function)
 
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TBX5 »  T-box transcription factor TBX5
 
Gene name:  TBX5
Entry whose protein(s) existence is based on evidence at protein level
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1 39 3
GENE REF ISO

Function

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Overview 
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977] silver  
  • IEAOrtholog Compara
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001228] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
2
  • IDAUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
4
  • IDAUniProtKB
  • IMPBHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
GO biological process 
Apoptotic nuclear changesdefinition[GO:0030262]  
1
  • IDAUniProtKB
Atrial septum morphogenesisdefinition[GO:0060413] silver  
  • IEAOrtholog Compara
Atrioventricular valve morphogenesisdefinition[GO:0003181] silver  
  • IEAOrtholog Compara
Bundle of His developmentdefinition[GO:0003166] silver  
  • IEAOrtholog Compara
Cardiac left ventricle formationdefinition[GO:0003218]  
  • ISSOrtholog Curator
Cardiac muscle cell differentiationdefinition[GO:0055007] silver  
  • IEAOrtholog Compara
Cell migration involved in coronary vasculogenesisdefinition[GO:0060980]  
1
  • TASDFLAT
Cell-cell signalingdefinition[GO:0007267]  
1
  • IDAUniProtKB
Embryonic forelimb morphogenesisdefinition[GO:0035115]  
1
  • IMPUniProtKB
Embryonic limb morphogenesisdefinition[GO:0030326]  
1
  • IMPUniProtKB
Endocardial cushion developmentdefinition[GO:0003197] silver  
  • IEAOrtholog Compara
Forelimb morphogenesisdefinition[GO:0035136]  
2
  • IMPMGI
Heart developmentdefinition[GO:0007507]  
4
  • IMPUniProtKB
  • IMPMGI
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Morphogenesis of an epitheliumdefinition[GO:0002009] silver  
  • IEAOrtholog Compara
Negative regulation of cardiac muscle cell proliferationdefinition[GO:0060044]  
1
  • IDAUniProtKB
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
2
  • IDAUniProtKB
Negative regulation of epithelial to mesenchymal transitiondefinition[GO:0010719]  
1
  • TASDFLAT
Pattern specification processdefinition[GO:0007389] silver  
  • IEAOrtholog Compara
Pericardium developmentdefinition[GO:0060039]  
1
  • IDAUniProtKB
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045] silver  
  • IEAOrtholog Compara
Positive regulation of cardioblast differentiationdefinition[GO:0051891]  
1
  • IDAUniProtKB
Positive regulation of secondary heart field cardioblast proliferationdefinition[GO:0072513] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPBHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
4
  • IDAUniProtKB
Regulation of execution phase of apoptosisdefinition[GO:1900117]  
1
  • ICUniProtKB
Ventricular cardiac muscle tissue developmentdefinition[GO:0003229] silver  
  • IEAOrtholog Compara
Ventricular septum developmentdefinition[GO:0003281]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathway:
YAP1- and WWTR1 (TAZ)-stimulated gene expression  REACT_118713  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TBX5_(gene)
GenomeRNAi: 6910
PRO: PR:Q99593