CCL13 - C-C motif chemokine 13 - human protein (Function)
 
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CCL13 »  C-C motif chemokine 13
 
Protein also known as:  Monocyte chemoattractant protein 4. Cleaved into:  C-C motif chemokine 13, long chain; C-C motif chemokine 13, medium chain; C-C motif chemokine 13, short chain.
Gene name:  CCL13
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.  
1
  • UniProtKB
GO molecular function 
Chemokine activitydefinition[GO:0008009]  
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  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
2
  • PINC
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • PINC
Chemotaxisdefinition[GO:0006935]  
1
  • PINC
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • UniProtKB
Eosinophil chemotaxisdefinition[GO:0048245]  
1
  • UniProtKB
Immune responsedefinition[GO:0006955] silver  
1
  • InterPro 2 GO
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB KW
Regulation of cell shapedefinition[GO:0008360]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
2
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+6357  
Cytokine-cytokine receptor interaction  hsa04060+6357  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Inflammatory response  definition   [KW-0395]
Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 6357
PRO: PR:Q99616