CDX2 - Homeobox protein CDX-2 - human protein (Function)
 
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CDX2 »  Homeobox protein CDX-2
 
Protein also known as:  Caudal-type homeobox protein 2.
Gene name:  CDX2
Family name: Caudal homeobox
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.  
1
  • UniProtKB
GO molecular function 
Double-stranded DNA bindingdefinition[GO:0003690] silver  
1
  • Ortholog Compara
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • NTNU_SB
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001227]  
1
  • NTNU_SB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • PINC
Transcription corepressor activitydefinition[GO:0003714] silver  
1
  • Ortholog Compara
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
1
  • Ortholog Compara
Blood vessel developmentdefinition[GO:0001568] silver  
1
  • Ortholog Compara
Endosome to lysosome transportdefinition[GO:0008333] silver  
1
  • Ortholog Compara
Establishment or maintenance of epithelial cell apical/basal polaritydefinition[GO:0045197] silver  
1
  • Ortholog Compara
Labyrinthine layer developmentdefinition[GO:0060711] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • NTNU_SB
Organ morphogenesisdefinition[GO:0009887]  
1
  • PINC
Positive regulation of cell differentiationdefinition[GO:0045597] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
1
  • Ortholog Compara
Somatic stem cell maintenancedefinition[GO:0035019] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • PINC
Trophectodermal cell differentiationdefinition[GO:0001829] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)  REACT_24019  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDX2
GenomeRNAi: 1045
PRO: PR:Q99626