CDX2 - Homeobox protein CDX-2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CDX2 »  Homeobox protein CDX-2
 
Protein also known as:  Caudal-type homeobox protein 2.
Gene name:  CDX2
Family name: Caudal homeobox
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 189 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.  
  • CuratedUniProtKB
GO molecular function 
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
Transcription corepressor activitydefinition[GO:0003714] silver  
  • IEAOrtholog Compara
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976] silver  
  • IEAInterPro 2 GO
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
Blood vessel developmentdefinition[GO:0001568] silver  
  • IEAOrtholog Compara
Endosome to lysosome transportdefinition[GO:0008333] silver  
  • IEAOrtholog Compara
Establishment or maintenance of epithelial cell apical/basal polaritydefinition[GO:0045197] silver  
  • IEAOrtholog Compara
Labyrinthine layer developmentdefinition[GO:0060711] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDANTNU_SB
Organ morphogenesisdefinition[GO:0009887]  
1
  • TASPINC
Positive regulation of cell differentiationdefinition[GO:0045597] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
  • IEAOrtholog Compara
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
Trophectodermal cell differentiationdefinition[GO:0001829] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDX2
GenomeRNAi: 1045
PRO: PR:Q99626