PITX2 - Pituitary homeobox 2 - human protein (Function)
 
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Protein
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PITX2 »  Pituitary homeobox 2
 
Protein also known as:  RIEG bicoid-related homeobox transcription factor.
Gene name:  PITX2
Family name: Paired homeobox » Bicoid
Entry whose protein(s) existence is based on evidence at protein level
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1 95 3
GENE REF ISO

Function

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Overview 
Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach.  
  • CuratedUniProtKB
Isoform  PTX2C   Is involved in left-right asymmetry the developing embryo (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Chromatin DNA bindingdefinition[GO:0031490] silver  
  • IEAOrtholog Compara
Isoform  PTX2C   Phosphoprotein bindingdefinition[GO:0051219]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Isoforms  PTX2C and PTX2A   Protein homodimerization activitydefinition[GO:0042803]  
2
  • IPIBHF-UCL
Isoform  PTX2C   Ribonucleoprotein complex bindingdefinition[GO:0043021]  
1
  • ICBHF-UCL
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
2
  • IPIBHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
  • IEAOrtholog Compara
Isoform  PTX2A   RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
1
  • IDABHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
RNA polymerase II transcription coactivator activitydefinition[GO:0001105]  
1
  • IDABHF-UCL
Isoform  PTX2A   RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • IPIBHF-UCL
Isoform  PTX2A   RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001191]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAMGI
Transcription factor bindingdefinition[GO:0008134]  
2
  • IPIUniProtKB
  • IPIMGI
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976]  
2
  • IDABHF-UCL
GO biological process 
Atrial cardiac muscle tissue morphogenesisdefinition[GO:0055009] silver  
  • IEAOrtholog Compara
Atrioventricular valve developmentdefinition[GO:0003171] silver  
  • IEAOrtholog Compara
Camera-type eye developmentdefinition[GO:0043010]  
1
  • IMPBHF-UCL
Cardiac neural crest cell migration involved in outflow tract morphogenesisdefinition[GO:0003253]  
  • ISSOrtholog Curator
Cell proliferation involved in outflow tract morphogenesisdefinition[GO:0061325]  
  • ISSOrtholog Curator
Deltoid tuberosity developmentdefinition[GO:0035993]  
1
  • IMPBHF-UCL
Determination of left/right symmetrydefinition[GO:0007368]  
  • ISSOrtholog Curator
Embryonic camera-type eye developmentdefinition[GO:0031076] silver  
  • IEAOrtholog Compara
Embryonic digestive tract morphogenesisdefinition[GO:0048557] silver  
  • IEAOrtholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
  • IEAOrtholog Compara
Endodermal digestive tract morphogenesisdefinition[GO:0061031] silver  
  • IEAOrtholog Compara
Extraocular skeletal muscle developmentdefinition[GO:0002074] silver  
  • IEAOrtholog Compara
Female gonad developmentdefinition[GO:0008585] silver  
  • IEAOrtholog Compara
Hair cell differentiationdefinition[GO:0035315]  
1
  • ICBHF-UCL
Hypothalamus cell migrationdefinition[GO:0021855] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Iris morphogenesisdefinition[GO:0061072]  
1
  • IMPBHF-UCL
Left lung morphogenesisdefinition[GO:0060460] silver  
  • IEAOrtholog Compara
Left/right axis specificationdefinition[GO:0070986]  
  • ISSOrtholog Curator
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Myoblast fusiondefinition[GO:0007520] silver  
  • IEAOrtholog Compara
Isoforms  PTX2C and PTX2A   Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • IDABHF-UCL
  • IDAGOC
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Odontogenesisdefinition[GO:0042476]  
1
  • IMPBHF-UCL
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Patterning of blood vesselsdefinition[GO:0001569] silver  
  • IEAOrtholog Compara
Positive regulation of DNA bindingdefinition[GO:0043388] silver  
  • IEAOrtholog Compara
Positive regulation of myoblast proliferationdefinition[GO:2000288] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
4
  • IDABHF-UCL
Prolactin secreting cell differentiationdefinition[GO:0060127]  
1
  • TASBHF-UCL
Pulmonary myocardium developmentdefinition[GO:0003350] silver  
  • IEAOrtholog Compara
Pulmonary vein morphogenesisdefinition[GO:0060577] silver  
  • IEAOrtholog Compara
Regulation of cell migrationdefinition[GO:0030334] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAMGI
Response to hormonedefinition[GO:0009725] silver  
  • IEAOrtholog Compara
Response to vitamin Adefinition[GO:0033189] silver  
  • IEAOrtholog Compara
Somatotropin secreting cell differentiationdefinition[GO:0060126]  
1
  • TASBHF-UCL
Spleen developmentdefinition[GO:0048536]  
  • ISSOrtholog Curator
Subthalamic nucleus developmentdefinition[GO:0021763] silver  
  • IEAOrtholog Compara
Superior vena cava morphogenesisdefinition[GO:0060578] silver  
  • IEAOrtholog Compara
Vascular smooth muscle cell differentiationdefinition[GO:0035886] silver  
  • IEAOrtholog Compara
Vasculogenesisdefinition[GO:0001570] silver  
  • IEAOrtholog Compara
Ventricular cardiac muscle cell developmentdefinition[GO:0055015] silver  
  • IEAOrtholog Compara
Ventricular septum morphogenesisdefinition[GO:0060412] silver  
  • IEAOrtholog Compara
Wnt signaling pathwaydefinition[GO:0016055] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+5308  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PITX2
GenomeRNAi: 5308
PRO: PR:Q99697