PITX2 - Pituitary homeobox 2 - human protein (Function)
 
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Protein
Gene
References

 
PITX2 »  Pituitary homeobox 2
 
Protein also known as:  RIEG bicoid-related homeobox transcription factor.
Gene name:  PITX2
Family name: Paired homeobox » Bicoid
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 122 3
GENE REF ISO

Function

 show evidences
Overview 
Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach.  
  • UniProtKB
Isoform  PTX2C   Is involved in left-right asymmetry the developing embryo (By similarity).  
1
  • UniProtKB
GO molecular function 
Isoform  PTX2A   Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Isoform  PTX2C   Phosphoprotein bindingdefinition[GO:0051219]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • BHF-UCL
Isoforms  PTX2C and PTX2A   Protein homodimerization activitydefinition[GO:0042803]  
2
  • BHF-UCL
Isoform  PTX2C   Ribonucleoprotein complex bindingdefinition[GO:0043021]  
1
  • BHF-UCL
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
2
  • BHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
RNA polymerase II transcription coactivator activitydefinition[GO:0001105]  
1
  • BHF-UCL
Isoform  PTX2A   RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • BHF-UCL
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
2
  • MGI
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
2
  • UniProtKB
  • MGI
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976]  
2
  • BHF-UCL
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0001077] silver  
1
  • Ortholog Compara
Isoform  PTX2A   Transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0001078]  
1
  • BHF-UCL
Isoform  PTX2A   Transcriptional repressor activity, RNA polymerase II transcription factor bindingdefinition[GO:0001191]  
1
  • BHF-UCL
GO biological process 
Camera-type eye developmentdefinition[GO:0043010]  
1
  • BHF-UCL
Cardiac neural crest cell migration involved in outflow tract morphogenesisdefinition[GO:0003253]  
1
  • Ortholog Curator
Cell proliferation involved in outflow tract morphogenesisdefinition[GO:0061325]  
1
  • Ortholog Curator
Deltoid tuberosity developmentdefinition[GO:0035993]  
1
  • BHF-UCL
Determination of left/right symmetrydefinition[GO:0007368]  
1
  • Ortholog Curator
Female gonad developmentdefinition[GO:0008585] silver  
1
  • Ortholog Compara
Hair cell differentiationdefinition[GO:0035315]  
1
  • BHF-UCL
Iris morphogenesisdefinition[GO:0061072]  
1
  • BHF-UCL
Left/right axis specificationdefinition[GO:0070986]  
1
  • Ortholog Curator
Male gonad developmentdefinition[GO:0008584] silver  
1
  • Ortholog Compara
Isoforms  PTX2C and PTX2A   Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • BHF-UCL
  • GOC
Odontogenesisdefinition[GO:0042476]  
1
  • BHF-UCL
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
4
  • BHF-UCL
Prolactin secreting cell differentiationdefinition[GO:0060127]  
1
  • BHF-UCL
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • MGI
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • MGI
  • UniProtKB
Response to hormonedefinition[GO:0009725] silver  
1
  • Ortholog Compara
Response to vitamin Adefinition[GO:0033189] silver  
1
  • Ortholog Compara
Somatotropin secreting cell differentiationdefinition[GO:0060126]  
1
  • BHF-UCL
Spleen developmentdefinition[GO:0048536]  
1
  • Ortholog Curator
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+5308  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PITX2
GenomeRNAi: 5308
PRO: PR:Q99697