PITX2 - Pituitary homeobox 2 - human protein (Sequence)
 
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Protein
Gene
References

 
PITX2 »  Pituitary homeobox 2
 
Protein also known as:  RIEG bicoid-related homeobox transcription factor.
Gene name:  PITX2
Family name: Paired homeobox » Bicoid
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 89 3
GENE REF ISO

Displayed isoform: PTX2B     

 
 
Isoform PTX2B   317 aaMass: 35370 Da,  pI: 9.53
METNCRKLVS ACVQLGVQPA AVECLFSKDS EIKKVEFTDS PESRKEAASS KFFPRQHPGA NEKDKSQQGK NEDVGAEDPS KKKRQRRQRT HFTSQQLQEL EATFQRNRYP DMSTREEIAV WTNLTEARVR VWFKNRRAKW RKRERNQQAE LCKNGFGPQF NGLMQPYDDM YPGYSYNNWA AKGLTSASLS TKSFPFFNSM NVNPLSSQSM FSPPNSISSM SMSSSMVPSA VTGVPGSSLN SLNNLNNLSS PSLNSAVPTP ACPYAPPTPP YVYRDTCNSS LASLRLKAKQ HSSFGYASVQ NPASNLSACQ YAVDRPV

Sequence

 show evidences
PTM 
Phosphorylation at Thr-90 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1 (By similarity).  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Domain 
Homeobox  definition   [KW-0371]
PTM 
Phosphoprotein  definition   [KW-0597]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 1.10.10.60
InterPro: IPR003654 [ OAR dom ]
InterPro: IPR009057 [ Homeodomain-like ]
InterPro: IPR017970 [ Homeobox CS ]
InterPro: IPR016233 [ Homeobox Pitx/unc30 ]
InterPro: IPR001356 [ Homeobox dom ]
Pfam: PF03826 [ OAR ]
Pfam: PF00046 [ Homeobox ]
PIRSF: PIRSF000563 [ Homeobox protein Pitx/Unc30 ]
PROSITE: PS00027 [ HOMEOBOX 1 ]
PROSITE: PS50803 [ OAR ]
PROSITE: PS50071 [ HOMEOBOX 2 ]
SMART: SM00389 [ HOX ]
SUPFAM: SSF46689 [ SSF46689 ]
Genome annotation databases
Ensembl: Transcript: ENST00000394598;  Protein: ENSP00000378097;  Gene: ENSG00000164093.
Ensembl: Transcript: ENST00000355080;  Protein: ENSP00000347192;  Gene: ENSG00000164093.
Ensembl: Transcript: ENST00000306732;  Protein: ENSP00000304169;  Gene: ENSG00000164093.
Ensembl: Transcript: ENST00000354925;  Protein: ENSP00000347004;  Gene: ENSG00000164093.
Ensembl: Transcript: ENST00000394595;  Protein: ENSP00000378095;  Gene: ENSG00000164093.
Ensembl: Transcript: ENST00000511837;  Protein: ENSP00000421454;  Gene: ENSG00000164093.
Ensembl: Transcript: ENST00000511990;  Protein: ENSP00000424142;  Gene: ENSG00000164093.
Ensembl: Transcript: ENST00000557119;  Protein: ENSP00000475617;  Gene: ENSG00000164093.
KEGG: hsa:5308
UCSC: uc003iad.3
Organism-specific databases
MGI: MGI:109340 [ Pitx2 ]
Other
ChiTaRS: PITX2
EvolutionaryTrace: Q99697
Phylogenomic databases
eggNOG: NOG249113
HOVERGEN: HBG068770
KO: K04686
OMA: DMYPSYT
OrthoDB: EOG7VTDNW
Sequence databases
CCDS: CCDS3692.1 [ Q99697-1 ]
CCDS: CCDS3694.1 [ Q99697-2 ]
CCDS: CCDS3693.1 [ Q99697-3 ]
EMBL: mRNA:  AK313987 . Translation:  BAG36699.1 .
EMBL: mRNA:  BC106010 . Translation:  AAI06011.1 .
EMBL: Genomic DNA:  CH471057 . Translation:  EAX06264.1 .
EMBL: Genomic DNA:  CH471057 . Translation:  EAX06263.1 .
EMBL: mRNA:  AF048721 . Translation:  AAC39717.1 .
EMBL: mRNA:  AK127829 . Translation:  BAG54582.1 .
EMBL: Genomic DNA:  CH471057 . Translation:  EAX06262.1 .
EMBL: mRNA:  AF048720 . Translation:  AAC39716.1 .
EMBL: mRNA:  BC013998 . Translation:  AAH13998.1 .
EMBL: Genomic DNA:  AF238048 . Translation:  AAK15048.1 .
EMBL: mRNA:  U69961 . Translation:  AAC16257.1 .
EMBL: mRNA:  AF048722 . Translation:  AAC39718.1 .
IPI: IPI00220801
IPI: IPI00220802
IPI: IPI00017093
RefSeq: Protein:  NP_001191327.1. Nucleotide sequence:  NM_001204398.1.
RefSeq: Protein:  NP_000316.2. Nucleotide sequence:  NM_000325.5.
RefSeq: Protein:  NP_001191326.1. Nucleotide sequence:  NM_001204397.1.
RefSeq: Protein:  NP_700475.1. Nucleotide sequence:  NM_153426.2.
RefSeq: Protein:  NP_700476.1. Nucleotide sequence:  NM_153427.2.
RefSeq: Protein:  NP_001191328.1. Nucleotide sequence:  NM_001204399.1.
UniProtKB: Q99697 [ PITX2 ]
Protocols and materials databases
DNASU: 5308