ATXN2 - Ataxin-2 - human protein (Function)
 
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Protein
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ATXN2 »  Ataxin-2
 
Protein also known as:  Trinucleotide repeat-containing gene 13 protein.
Gene name:  ATXN2
Family name: Ataxin-2
Entry whose protein(s) existence is based on evidence at protein level
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1 105 4
GENE REF ISO

Function

 show evidences
Overview 
Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.  
1
  • CuratedUniProtKB
GO molecular function 
Epidermal growth factor receptor bindingdefinition[GO:0005154]  
1
  • IPIUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
10
  • IPIIntAct
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723]  
1
  • NASUniProtKB
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cerebellar Purkinje cell differentiationdefinition[GO:0021702] silver  
  • IEAOrtholog Compara
Cytoplasmic mRNA processing body assemblydefinition[GO:0033962]  
1
  • IMPUniProtKB
Homeostasis of number of cellsdefinition[GO:0048872] silver  
  • IEAOrtholog Compara
Negative regulation of multicellular organism growthdefinition[GO:0040015] silver  
  • IEAOrtholog Compara
Negative regulation of receptor internalizationdefinition[GO:0002091]  
1
  • IMPUniProtKB
Neuromuscular processdefinition[GO:0050905] silver  
  • IEAOrtholog Compara
Neuron projection morphogenesisdefinition[GO:0048812] silver  
  • IEAOrtholog Compara
Regulation of translationdefinition[GO:0006417]  
1
  • NASUniProtKB
RNA metabolic processdefinition[GO:0016070]  
1
  • NASUniProtKB
RNA transportdefinition[GO:0050658]  
1
  • NASUniProtKB
Stress granule assemblydefinition[GO:0034063]  
1
  • IMPUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATXN2
GenomeRNAi: 6311
PRO: PR:Q99700