MTR - Methionine synthase - human protein (Function)
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MTR »  Methionine synthase   [ EC ]
Protein also known as:  5-methyltetrahydrofolate--homocysteine methyltransferase.
Gene name:  MTR
Entry whose protein(s) existence is based on evidence at protein level
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Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Cobalamin bindingdefinition[GO:0031419]  
  • IEAUniProtKB KW
Methionine synthase activitydefinition[GO:0008705]  
  • IEAEC 2 GO
S-adenosylmethionine-homocysteine S-methyltransferase activitydefinition[GO:0008898] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Methionine biosynthetic processdefinition[GO:0009086] silver  
  • IEAOrtholog Compara
Nervous system developmentdefinition[GO:0007399]  
Pteridine-containing compound metabolic processdefinition[GO:0042558] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5-methyltetrahydrofolate + L-homocysteine tetrahydrofolate + L-methionine.  
  • CuratedUniProtKB
It requires the following cofactors
Methylcobalamin (MeCBL).  
  • CuratedUniProtKB
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+4548  
Metabolic pathways  hsa01100+4548  
One carbon pool by folate  hsa00670+4548  
Selenocompound metabolism  hsa00450+4548  
According to Reactome, this protein belongs to the following pathways:
Cobalamin (Cbl, vitamin B12) transport and metabolism  REACT_163862  
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG  REACT_169149  
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE  REACT_169439  
Methylation  REACT_6946  
Sulfur amino acid metabolism  REACT_115639  
More information is available from:
L-homocysteine is bound via the zinc atom (By similarity).  
  • CuratedUniProtKB


Biological process 
Amino-acid biosynthesis  definition   [KW-0028]
Methionine biosynthesis  definition   [KW-0486]
Molecular function 
Methyltransferase  definition   [KW-0489]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: Methionine_synthase
GenomeRNAi: 4548
PRO: PR:Q99707