SIGMAR1 - Sigma non-opioid intracellular receptor 1 - human protein (Function)
 
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SIGMAR1 »  Sigma non-opioid intracellular receptor 1
 
Protein also known as:  Aging-associated gene 8 protein.
Gene name:  SIGMAR1
Family name: ERG2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.  
2
  • CuratedUniProtKB
GO molecular function 
Drug bindingdefinition[GO:0008144]  
1
  • TASPINC
Opioid receptor activitydefinition[GO:0004985] silver  
  • IEAOrtholog Compara
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Lipid transportdefinition[GO:0006869]  
  • IEAUniProtKB KW
Nervous system developmentdefinition[GO:0007399] silver  
  • IEAOrtholog Compara
Regulation of neuron apoptotic processdefinition[GO:0043523]  
1
  • IMPUniProtKB
Note 
Depletion by RNAi inhibits growth and survival signaling cascades and induces cell death. The antagonist rimcazole produces the same effect.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Sigma-1_receptor
GenomeRNAi: 10280
PRO: PR:Q99720
Chemistry
GuidetoPHARMACOLOGY: 2552