NPAS2 - Neuronal PAS domain-containing protein 2 - human protein (Function)
 
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Protein
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References

 
NPAS2 »  Neuronal PAS domain-containing protein 2  (Neuronal PAS2)
 
Protein also known as:  Class E basic helix-loop-helix protein 9 (bHLHe9).
Gene name:  NPAS2
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

 show evidences
Overview 
BMAL1-NPAS2 heterodimers activate E-box element (5'-CACGTG-3') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Core promoter bindingdefinition[GO:0001047]  
  • ISSOrtholog Curator
DNA bindingdefinition[GO:0003677]  
1
  • IPIMGI
Hsp90 protein bindingdefinition[GO:0051879]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
GO biological process 
Central nervous system developmentdefinition[GO:0007417]  
1
  • TASPINC
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Circadian sleep/wake cycledefinition[GO:0042745] silver  
  • IEAOrtholog Compara
Locomotor rhythmdefinition[GO:0045475] silver  
  • IEAOrtholog Compara
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • IMPUniProtKB
Positive regulation of DNA repairdefinition[GO:0045739]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IGIMGI
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IMPUniProtKB
Regulation of response to DNA damage stimulusdefinition[GO:2001020]  
1
  • IMPUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Circadian rhythm - mammal  hsa04710+4862  
According to Reactome, this protein belongs to the following pathways:
Circadian Clock  REACT_24941  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NPAS2
GenomeRNAi: 4862
PRO: PR:Q99743