PIP5K1A - Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha - human protein (Function)
 
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PIP5K1A »  Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
 
Gene name:  PIP5K1A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.  
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  • CuratedUniProtKB
GO molecular function 
1-phosphatidylinositol-4-phosphate 5-kinase activitydefinition[GO:0016308]  
2
  • TASUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Kinase bindingdefinition[GO:0019900]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • IMPUniProtKB
Activation of Rac GTPase activitydefinition[GO:0032863]  
1
  • IMPUniProtKB
Cell chemotaxisdefinition[GO:0060326]  
1
  • IMPUniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • NASUniProtKB
Fibroblast migrationdefinition[GO:0010761] silver  
  • IEAOrtholog Compara
Focal adhesion assemblydefinition[GO:0048041]  
1
  • IMPUniProtKB
Glycerophospholipid metabolic processdefinition[GO:0006650]  
1
  • TASPINC
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • TASUniProtKB
Phagocytosisdefinition[GO:0006909]  
1
  • TASUniProtKB
Phosphatidylinositol phosphorylationdefinition[GO:0046854]  
2
  • TASGOC
  • IEAOrtholog Compara
  • IEAEC 2 GO
  • IEAInterPro 2 GO
Phospholipid biosynthetic processdefinition[GO:0008654]  
1
  • IDAUniProtKB
Protein targeting to plasma membranedefinition[GO:0072661]  
1
  • IMPUniProtKB
Ruffle assemblydefinition[GO:0097178]  
1
  • IMPUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.68: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Endocytosis  hsa04144+8394  
Fc gamma R-mediated phagocytosis  hsa04666+8394  
Inositol phosphate metabolism  hsa00562+8394  
Metabolic pathways  hsa01100+8394  
Phosphatidylinositol signaling system  hsa04070+8394  
Regulation of actin cytoskeleton  hsa04810+8394  
According to Reactome, this protein belongs to the following pathway:
Synthesis of PIPs at the plasma membrane  REACT_121025  
 
More information is available from:
Caution 
There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PIP5K1A
GenomeRNAi: 8394
PRO: PR:Q99755
Chemistry
GuidetoPHARMACOLOGY: 2164