MAP3K3 - Mitogen-activated protein kinase kinase kinase 3 - human protein (Function)
 
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MAP3K3 »  Mitogen-activated protein kinase kinase kinase 3   [ EC 2.7.11.25 ]
 
Protein also known as:  MAPK/ERK kinase kinase 3 (MEKK 3).
Gene name:  MAP3K3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
MAP kinase kinase kinase activitydefinition[GO:0004709]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • IDAMGI
GO biological process 
Activation of MAPKK activitydefinition[GO:0000186]  
1
  • TASGOC
  • IEAEC 2 GO
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAMGI
MAPK cascadedefinition[GO:0000165]  
1
  • TASPINC
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IEPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAMGI
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation on Thr-530 (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
GnRH signaling pathway  hsa04912+4215  
HTLV-I infection  hsa05166+4215  
MAPK signaling pathway  hsa04010+4215  
Neurotrophin signaling pathway  hsa04722+4215  
According to Reactome, this protein belongs to the following pathway:
Interleukin-1 signaling  REACT_22442  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP3K3
GenomeRNAi: 4215
PRO: PR:Q99759
Chemistry
GuidetoPHARMACOLOGY: 2078