ACO2 - Aconitate hydratase, mitochondrial - human protein (Function)
 
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ACO2 »  Aconitate hydratase, mitochondrial   [ EC 4.2.1.3 ]  (Aconitase)
 
Protein also known as:  Citrate hydro-lyase.
Gene name:  ACO2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.  
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  • UniProtKB
GO molecular function 
3 iron, 4 sulfur cluster bindingdefinition[GO:0051538] silver  
1
  • Ortholog Compara
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
1
  • UniProtKB KW
Aconitate hydratase activitydefinition[GO:0003994]  
1
  • EC 2 GO
Iron ion bindingdefinition[GO:0005506]  
1
  • MGI
GO biological process 
Citrate metabolic processdefinition[GO:0006101]  
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  • MGI
Generation of precursor metabolites and energydefinition[GO:0006091]  
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  • PINC
Isocitrate metabolic processdefinition[GO:0006102] silver  
1
  • Ortholog Compara
Tricarboxylic acid cycledefinition[GO:0006099]  
2
  • MGI
  • UniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.3: Citrate isocitrate.  
1
  • UniProtKB
It requires the following cofactor
 [4Fe-4S] cluster : Binds 1 [4Fe-4S] cluster per subunit. Binding of a [3Fe-4S] cluster leads to an inactive enzyme.  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+50  
Glyoxylate and dicarboxylate metabolism  hsa00630+50  
Metabolic pathways  hsa01100+50  
According to Reactome, this protein belongs to the following pathways:
Citric acid cycle (TCA cycle)  REACT_1785  
Mitochondrial protein import  REACT_118595  
 
More information is available from:
 

Keywords

Biological process 
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 50
PRO: PR:Q99798