ACO2 - Aconitate hydratase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
ACO2 »  Aconitate hydratase, mitochondrial
 
Gene name:  ACO2
Entry whose protein(s) existence is based on evidence at protein level
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1 36 1
GENE REF ISO

Function

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Overview 
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).  
  • CuratedUniProtKB
GO molecular function 
3 iron, 4 sulfur cluster bindingdefinition[GO:0051538] silver  
  • IEAOrtholog Compara
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539] silver  
  • IEAOrtholog Compara
Aconitate hydratase activitydefinition[GO:0003994]  
  • IEAEC 2 GO
Iron ion bindingdefinition[GO:0005506]  
1
  • IDAMGI
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Citrate metabolic processdefinition[GO:0006101]  
1
  • IDAMGI
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Isocitrate metabolic processdefinition[GO:0006102] silver  
  • IEAOrtholog Compara
Tricarboxylic acid cycledefinition[GO:0006099]  
1
  • IDAMGI
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.3: Citrate isocitrate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 4Fe-4S cluster per subunit. Binding of a 3Fe-4S cluster leads to an inactive enzyme (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+50  
Glyoxylate and dicarboxylate metabolism  hsa00630+50  
Metabolic pathways  hsa01100+50  
According to Reactome, this protein belongs to the following pathways:
Citric acid cycle (TCA cycle)  REACT_1785  
Mitochondrial protein import  REACT_118595  
 
More information is available from:
 

Keywords

Biological process 
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 50
PRO: PR:Q99798