SLC29A1 - Equilibrative nucleoside transporter 1 - human protein (Function)
 
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References

 
SLC29A1 »  Equilibrative nucleoside transporter 1
 
Protein also known as:  Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter (Equilibrative NBMPR-sensitive nucleoside transporter).
Gene name:  SLC29A1
Entry whose protein(s) existence is based on evidence at protein level
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1 102 1
GENE REF ISO

Function

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Overview 
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the equilibrative nucleoside transporter (ent) family  2.A.57.1.1  
GO molecular function 
Nucleoside transmembrane transporter activitydefinition[GO:0005337] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Nucleobase-containing compound metabolic processdefinition[GO:0006139]  
1
  • TASPINC
Nucleoside transmembrane transportdefinition[GO:1901642]  
1
  • TASGOC
  • IEAOrtholog Compara
  • IEAInterPro 2 GO
Nucleoside transportdefinition[GO:0015858]  
1
  • IDAUniProtKB
Regulation of excitatory postsynaptic membrane potentialdefinition[GO:0060079] silver  
  • IEAOrtholog Compara
Sleepdefinition[GO:0030431] silver  
  • IEAOrtholog Compara
Uridine transportdefinition[GO:0015862] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane  REACT_1206  
 

Biophysicochemical properties

Kinetic parameters
Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.
KM 0.62 mM for adenosine

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Equilibrative_nucleoside_transporter_1
GenomeRNAi: 2030
PRO: PR:Q99808
Chemistry
GuidetoPHARMACOLOGY: 1117