EPAS1 - Endothelial PAS domain-containing protein 1 - human protein (Function)
 
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Protein
Gene
References

 
EPAS1 »  Endothelial PAS domain-containing protein 1  (EPAS-1)
 
Protein also known as:  Class E basic helix-loop-helix protein 73 (bHLHe73).
Gene name:  EPAS1
Entry whose protein(s) existence is based on evidence at protein level
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1 269 1
GENE REF ISO

Function

 show evidences
Overview 
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.  
1
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • MGI
Histone acetyltransferase bindingdefinition[GO:0035035]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
9
  • IntAct
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • BHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
1
  • Ortholog Compara
Contributes to sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • BHF-UCL
Signal transducer activitydefinition[GO:0004871] silver  
1
  • InterPro 2 GO
Transcription factor bindingdefinition[GO:0008134]  
1
  • BHF-UCL
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
1
  • Ortholog Compara
Blood vessel remodelingdefinition[GO:0001974] silver  
1
  • Ortholog Compara
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Cellular response to hypoxiadefinition[GO:0071456]  
1
  • UniProtKB
Embryonic placenta developmentdefinition[GO:0001892] silver  
1
  • Ortholog Compara
Erythrocyte differentiationdefinition[GO:0030218] silver  
1
  • Ortholog Compara
Iron ion homeostasisdefinition[GO:0055072] silver  
1
  • Ortholog Compara
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Mitochondrion organizationdefinition[GO:0007005] silver  
1
  • Ortholog Compara
Myoblast fate commitmentdefinition[GO:0048625]  
1
  • Ortholog Curator
Norepinephrine metabolic processdefinition[GO:0042415] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • UniProtKB
  • MGI
Regulation of heart ratedefinition[GO:0002027] silver  
1
  • Ortholog Compara
Regulation of transcription from RNA polymerase II promoter in response to oxidative stressdefinition[GO:0043619] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666]  
1
  • MGI
Signal transductiondefinition[GO:0007165] silver  
1
  • InterPro 2 GO
Surfactant homeostasisdefinition[GO:0043129] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • PINC
Visual perceptiondefinition[GO:0007601] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Pathways in cancer  hsa05200+2034  
Renal cell carcinoma  hsa05211+2034  
According to Reactome, this protein belongs to the following pathways:
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha  REACT_121226  
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha  REACT_120916  
Regulation of gene expression by Hypoxia-inducible Factor  REACT_121092  
Transcriptional regulation of pluripotent stem cells  REACT_263856  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EPAS1
GenomeRNAi: 2034
PRO: PR:Q99814