SMO - Smoothened homolog - human protein (Function)
 
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SMO »  Smoothened homolog  (SMO)
 
Protein also known as:  Protein Gx.
Gene name:  SMO
Entry whose protein(s) existence is based on evidence at protein level
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1 79 1
GENE REF ISO

Function

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Overview 
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.  
1
  • CuratedUniProtKB
GO molecular function 
Drug bindingdefinition[GO:0008144]  
2
  • IDAUniProtKB
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
Patched bindingdefinition[GO:0005113]  
1
  • IPIBHF-UCL
PDZ domain bindingdefinition[GO:0030165] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Wnt-activated receptor activitydefinition[GO:0042813] silver  
  • IBARefGenome
Wnt-protein bindingdefinition[GO:0017147] silver  
  • IBARefGenome
GO biological process 
Adenohypophysis developmentdefinition[GO:0021984] silver  
  • IBARefGenome
Atrial septum morphogenesisdefinition[GO:0060413] silver  
  • IEAOrtholog Compara
Axon extension involved in axon guidancedefinition[GO:0048846] silver  
  • IBARefGenome
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IBARefGenome
Cardioblast differentiationdefinition[GO:0010002] silver  
  • IBARefGenome
Cell fate specificationdefinition[GO:0001708] silver  
  • IEAOrtholog Compara
Cellular response to cholesteroldefinition[GO:0071397]  
  • ISSOrtholog Curator
Central nervous system neuron differentiationdefinition[GO:0021953] silver  
  • IBARefGenome
Cerebellar cortex morphogenesisdefinition[GO:0021696] silver  
  • IBARefGenome
Ciliary receptor clustering involved in smoothened signaling pathwaydefinition[GO:0060830] silver  
  • IBARefGenome
Detection of cell density by contact stimulus involved in contact inhibitiondefinition[GO:0060248]  
1
  • IMPBHF-UCL
Determination of left/right asymmetry in lateral mesodermdefinition[GO:0003140]  
  • ISSOrtholog Curator
Determination of left/right symmetrydefinition[GO:0007368] silver  
  • IBARefGenome
Dorsal/ventral neural tube patterningdefinition[GO:0021904] silver  
  • IBARefGenome
Embryonic camera-type eye developmentdefinition[GO:0031076] silver  
  • IBARefGenome
Embryonic digestive tract morphogenesisdefinition[GO:0048557] silver  
  • IBARefGenome
Embryonic neurocranium morphogenesisdefinition[GO:0048702] silver  
  • IBARefGenome
Embryonic viscerocranium morphogenesisdefinition[GO:0048703] silver  
  • IBARefGenome
Epithelial-mesenchymal cell signalingdefinition[GO:0060684] silver  
  • IEAOrtholog Compara
Exocrine pancreas developmentdefinition[GO:0031017] silver  
  • IBARefGenome
Facial nerve developmentdefinition[GO:0021561] silver  
  • IBARefGenome
Floor plate formationdefinition[GO:0021508] silver  
  • IBARefGenome
Forebrain morphogenesisdefinition[GO:0048853]  
  • ISSOrtholog Curator
Gonad developmentdefinition[GO:0008406] silver  
  • IBARefGenome
Hair follicle morphogenesisdefinition[GO:0031069] silver  
  • IEAOrtholog Compara
Heart loopingdefinition[GO:0001947]  
  • ISSOrtholog Curator
Heart morphogenesisdefinition[GO:0003007] silver  
  • IBARefGenome
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Mammary gland epithelial cell differentiationdefinition[GO:0060644] silver  
  • IEAOrtholog Compara
Mesenchymal to epithelial transition involved in metanephric renal vesicle formationdefinition[GO:0072285]  
  • ISSOrtholog Curator
Midgut developmentdefinition[GO:0007494]  
  • ISSOrtholog Curator
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Muscle cell fate commitmentdefinition[GO:0042693] silver  
  • IBARefGenome
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IBARefGenome
Negative regulation of DNA bindingdefinition[GO:0043392]  
  • ISSOrtholog Curator
Negative regulation of epithelial cell differentiationdefinition[GO:0030857] silver  
  • IEAOrtholog Compara
Negative regulation of gene expressiondefinition[GO:0010629]  
  • ISSOrtholog Curator
Negative regulation of hair follicle developmentdefinition[GO:0051799] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Neural crest cell migrationdefinition[GO:0001755] silver  
  • IBARefGenome
Neuron fate commitmentdefinition[GO:0048663] silver  
  • IBARefGenome
Neuron projection regenerationdefinition[GO:0031102] silver  
  • IBARefGenome
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IBARefGenome
Osteoblast differentiationdefinition[GO:0001649] silver  
  • IBARefGenome
Otolith morphogenesisdefinition[GO:0032474] silver  
  • IBARefGenome
Pancreas morphogenesisdefinition[GO:0061113] silver  
  • IEAOrtholog Compara
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190]  
  • ISSOrtholog Curator
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IBARefGenome
Positive regulation of gene expressiondefinition[GO:0010628]  
  • ISSOrtholog Curator
Positive regulation of hh target transcription factor activitydefinition[GO:0007228]  
  • ISSOrtholog Curator
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
  • IBARefGenome
Positive regulation of neuroblast proliferationdefinition[GO:0002052] silver  
  • IBARefGenome
Positive regulation of protein import into nucleusdefinition[GO:0042307] silver  
  • IEAOrtholog Compara
Positive regulation of smoothened signaling pathwaydefinition[GO:0045880] silver  
  • IBARefGenome
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Protein localization to nucleusdefinition[GO:0034504] silver  
  • IEAOrtholog Compara
Protein stabilizationdefinition[GO:0050821] silver  
  • IEAOrtholog Compara
Regulation of heart morphogenesisdefinition[GO:2000826]  
  • ISSOrtholog Curator
Regulation of stem cell maintenancedefinition[GO:2000036] silver  
  • IEAOrtholog Compara
Renal system developmentdefinition[GO:0072001]  
1
  • IEPUniProtKB
Semicircular canal morphogenesisdefinition[GO:0048752] silver  
  • IBARefGenome
Smoothened signaling pathwaydefinition[GO:0007224]  
4
  • IMPUniProtKB
  • IMPBHF-UCL
Smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationdefinition[GO:0021938] silver  
  • IBARefGenome
Smoothened signaling pathway involved in ventral spinal cord patterningdefinition[GO:0021910] silver  
  • IBARefGenome
Somite developmentdefinition[GO:0061053]  
  • ISSOrtholog Curator
Spermatogenesisdefinition[GO:0007283] silver  
  • IBARefGenome
Thalamus developmentdefinition[GO:0021794] silver  
  • IEAOrtholog Compara
Type B pancreatic cell developmentdefinition[GO:0003323] silver  
  • IEAOrtholog Compara
Vasculogenesisdefinition[GO:0001570] silver  
  • IBARefGenome
Ventral midline determinationdefinition[GO:0007371]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+6608  
Hedgehog signaling pathway  hsa04340+6608  
Pathways in cancer  hsa05200+6608  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Smoothened
GenomeRNAi: 6608
PRO: PR:Q99835