SMO - Smoothened homolog - human protein (Function)
 
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SMO »  Smoothened homolog  (SMO)
 
Protein also known as:  Protein Gx.
Gene name:  SMO
Entry whose protein(s) existence is based on evidence at protein level
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1 88 1
GENE REF ISO

Function

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Overview 
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.  
2
  • UniProtKB
GO molecular function 
Drug bindingdefinition[GO:0008144]  
2
  • UniProtKB
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • RefGenome
Patched bindingdefinition[GO:0005113]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Not  Wnt-activated receptor activitydefinition[GO:0042813]  
1
  • RefGenome
Wnt-protein bindingdefinition[GO:0017147]  
1
  • RefGenome
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
1
  • Ortholog Compara
Atrial septum morphogenesisdefinition[GO:0060413] silver  
1
  • Ortholog Compara
Not  Canonical Wnt signaling pathwaydefinition[GO:0060070]  
1
  • RefGenome
Cell fate specificationdefinition[GO:0001708] silver  
1
  • Ortholog Compara
Cellular response to cholesteroldefinition[GO:0071397]  
1
  • Ortholog Curator
Central nervous system neuron differentiationdefinition[GO:0021953] silver  
1
  • Ortholog Compara
Cerebellar cortex morphogenesisdefinition[GO:0021696] silver  
1
  • Ortholog Compara
Detection of cell density by contact stimulus involved in contact inhibitiondefinition[GO:0060248]  
1
  • BHF-UCL
Determination of left/right asymmetry in lateral mesodermdefinition[GO:0003140]  
1
  • Ortholog Curator
Developmental growthdefinition[GO:0048589] silver  
1
  • Ortholog Compara
Dorsal/ventral neural tube patterningdefinition[GO:0021904] silver  
1
  • Ortholog Compara
Epithelial-mesenchymal cell signalingdefinition[GO:0060684] silver  
1
  • Ortholog Compara
Forebrain morphogenesisdefinition[GO:0048853]  
1
  • Ortholog Curator
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Hair follicle morphogenesisdefinition[GO:0031069] silver  
1
  • Ortholog Compara
Heart loopingdefinition[GO:0001947]  
1
  • Ortholog Curator
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Mammary gland epithelial cell differentiationdefinition[GO:0060644] silver  
1
  • Ortholog Compara
Mesenchymal to epithelial transition involved in metanephric renal vesicle formationdefinition[GO:0072285]  
1
  • Ortholog Curator
Midgut developmentdefinition[GO:0007494]  
1
  • Ortholog Curator
Multicellular organism growthdefinition[GO:0035264] silver  
1
  • Ortholog Compara
Myoblast migrationdefinition[GO:0051451] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Negative regulation of DNA bindingdefinition[GO:0043392]  
1
  • Ortholog Curator
Negative regulation of epithelial cell differentiationdefinition[GO:0030857] silver  
1
  • Ortholog Compara
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • Ortholog Curator
Negative regulation of hair follicle developmentdefinition[GO:0051799] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Neural crest cell migrationdefinition[GO:0001755] silver  
1
  • Ortholog Compara
Not  Non-canonical Wnt signaling pathwaydefinition[GO:0035567]  
1
  • RefGenome
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Osteoblast differentiationdefinition[GO:0001649] silver  
1
  • Ortholog Compara
Pancreas morphogenesisdefinition[GO:0061113] silver  
1
  • Ortholog Compara
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190]  
1
  • Ortholog Curator
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • Ortholog Curator
Positive regulation of hh target transcription factor activitydefinition[GO:0007228]  
1
  • Ortholog Curator
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
1
  • Ortholog Compara
Positive regulation of neuroblast proliferationdefinition[GO:0002052] silver  
1
  • Ortholog Compara
Positive regulation of protein import into nucleusdefinition[GO:0042307] silver  
1
  • Ortholog Compara
Positive regulation of smoothened signaling pathwaydefinition[GO:0045880] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Protein localization to nucleusdefinition[GO:0034504] silver  
1
  • Ortholog Compara
Protein stabilizationdefinition[GO:0050821] silver  
1
  • Ortholog Compara
Regulation of heart morphogenesisdefinition[GO:2000826]  
1
  • Ortholog Curator
Regulation of stem cell maintenancedefinition[GO:2000036] silver  
1
  • Ortholog Compara
Renal system developmentdefinition[GO:0072001]  
1
  • UniProtKB
Skeletal muscle fiber developmentdefinition[GO:0048741] silver  
1
  • Ortholog Compara
Smoothened signaling pathwaydefinition[GO:0007224]  
4
  • UniProtKB
  • BHF-UCL
Smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationdefinition[GO:0021938] silver  
1
  • Ortholog Compara
Smoothened signaling pathway involved in ventral spinal cord patterningdefinition[GO:0021910] silver  
1
  • Ortholog Compara
Somite developmentdefinition[GO:0061053]  
1
  • Ortholog Curator
Thalamus developmentdefinition[GO:0021794] silver  
1
  • Ortholog Compara
Type B pancreatic cell developmentdefinition[GO:0003323] silver  
1
  • Ortholog Compara
Vasculogenesisdefinition[GO:0001570] silver  
1
  • Ortholog Compara
Ventral midline determinationdefinition[GO:0007371]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+6608  
Hedgehog signaling pathway  hsa04340+6608  
Pathways in cancer  hsa05200+6608  
According to Reactome, this protein belongs to the following pathways:
Activation of SMO  REACT_267753  
BBSome-mediated cargo-targeting to cilium  REACT_267948  
Class B/2 (Secretin family receptors)  REACT_18372  
Hedgehog 'off' state  REACT_268323  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Smoothened
GenomeRNAi: 6608
PRO: PR:Q99835
Chemistry
GuidetoPHARMACOLOGY: 239