PRMT1 - Protein arginine N-methyltransferase 1 - human protein (Function)
 
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PRMT1 »  Protein arginine N-methyltransferase 1   [ EC 2.1.1.- ]
 
Protein also known as:  Histone-arginine N-methyltransferase PRMT1 [EC 2.1.1.125].
Gene name:  PRMT1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity.  
11
  • UniProtKB
GO molecular function 
Histone methyltransferase activitydefinition[GO:0042054]  
1
  • UniProtKB
Histone methyltransferase activity (H4-R3 specific)definition[GO:0044020]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IntAct
Methyltransferase activitydefinition[GO:0008168]  
1
  • PINC
N-methyltransferase activitydefinition[GO:0008170]  
2
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
12
  • IntAct
  • UniProtKB
  • HGNC
Protein-arginine omega-N asymmetric methyltransferase activitydefinition[GO:0035242]  
1
  • RefGenome
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Histone H4-R3 methylationdefinition[GO:0043985]  
1
  • UniProtKB
Histone methylationdefinition[GO:0016571]  
1
  • UniProtKB
Negative regulation of megakaryocyte differentiationdefinition[GO:0045653]  
1
  • UniProtKB
Neuron projection developmentdefinition[GO:0031175]  
1
  • UniProtKB
Peptidyl-arginine methylationdefinition[GO:0018216]  
1
  • UniProtKB
Peptidyl-arginine methylation, to asymmetrical-dimethyl argininedefinition[GO:0019919]  
1
  • RefGenome
Protein methylationdefinition[GO:0006479]  
1
  • PINC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.1.1.125: S-adenosyl-L-methionine + arginine-[histone] S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].  
4
  • UniProtKB
It is regulated in the following manner
By BTG1, BTG2 and ILF3.  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
RMTs methylate histone arginines  REACT_228108  
 

Biophysicochemical properties

Kinetic parameters
KM 1 uM for AdoMet
KM 4.2 uM for H4
Vmax 1.2 nmol/min/mg enzyme toward AdoMet
Vmax 1.24 nmol/min/mg enzyme toward H4

Keywords

Molecular function 
Methyltransferase  definition   [KW-0489]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q99873
Other
GeneWiki: PRMT1
GenomeRNAi: 3276
PRO: PR:Q99873
Chemistry
GuidetoPHARMACOLOGY: 1252