PRMT1 - Protein arginine N-methyltransferase 1 - human protein (Function)
 
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PRMT1 »  Protein arginine N-methyltransferase 1   [ EC 2.1.1.- ]
 
Protein also known as:  Histone-arginine N-methyltransferase PRMT1 [EC 2.1.1.125].
Gene name:  PRMT1
Entry whose protein(s) existence is based on evidence at protein level
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1 48 4
GENE REF ISO

Function

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Overview 
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity.  
10
  • CuratedUniProtKB
GO molecular function 
Histone methyltransferase activitydefinition[GO:0042054]  
1
  • IDAUniProtKB
Histone methyltransferase activity (H4-R3 specific)definition[GO:0044020]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Methyltransferase activitydefinition[GO:0008168]  
1
  • TASPINC
N-methyltransferase activitydefinition[GO:0008170]  
2
  • IMPUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
12
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
Protein-arginine omega-N asymmetric methyltransferase activitydefinition[GO:0035242] silver  
  • IBARefGenome
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Histone H4-R3 methylationdefinition[GO:0043985]  
1
  • IDAUniProtKB
Histone methylationdefinition[GO:0016571]  
1
  • IDAUniProtKB
Negative regulation of megakaryocyte differentiationdefinition[GO:0045653]  
1
  • IDAUniProtKB
Neuron projection developmentdefinition[GO:0031175]  
1
  • IMPUniProtKB
Peptidyl-arginine methylationdefinition[GO:0018216]  
1
  • IDAUniProtKB
Peptidyl-arginine methylation, to asymmetrical-dimethyl argininedefinition[GO:0019919] silver  
  • IBARefGenome
Protein methylationdefinition[GO:0006479]  
1
  • TASPINC
Regulation of transcription, DNA-templateddefinition[GO:0006355] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.1.1.125: S-adenosyl-L-methionine + arginine-[histone] S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].  
3
  • CuratedUniProtKB
It is regulated in the following manner
By BTG1, BTG2 and ILF3.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 1 uM for AdoMet
KM 4.2 uM for H4
Vmax 1.2 nmol/min/mg enzyme toward AdoMet
Vmax 1.24 nmol/min/mg enzyme toward H4

Keywords

Molecular function 
Methyltransferase  definition   [KW-0489]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q99873
Other
GeneWiki: PRMT1
GenomeRNAi: 3276
PRO: PR:Q99873