ASCL2 - Achaete-scute homolog 2 - human protein (Function)
 
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Protein
Gene
References

 
ASCL2 »  Achaete-scute homolog 2  (ASH-2)
 
Protein also known as:  Class A basic helix-loop-helix protein 45 (bHLHa45).
Gene name:  ASCL2
Entry whose protein(s) existence is based on evidence at protein level
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1 16 1
GENE REF ISO

Function

 show evidences
Overview 
AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.  
  • CuratedUniProtKB
GO molecular function 
E-box bindingdefinition[GO:0070888]  
1
  • IDAUniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • NASUniProtKB
GO biological process 
Negative regulation of Schwann cell proliferationdefinition[GO:0010626] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Placenta developmentdefinition[GO:0001890]  
1
  • NASUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Response to hypoxiadefinition[GO:0001666]  
1
  • IEPUniProtKB
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
Spongiotrophoblast differentiationdefinition[GO:0060708] silver  
  • IEAOrtholog Compara
Spongiotrophoblast layer developmentdefinition[GO:0060712]  
1
  • IEPUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • IDAUniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ASCL2
GenomeRNAi: 430
PRO: PR:Q99929