BAG1 - BAG family molecular chaperone regulator 1 - human protein (Function)
 
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Protein
Gene
References

 
BAG1 »  BAG family molecular chaperone regulator 1  (BAG-1)
 
Protein also known as:  Bcl-2-associated athanogene 1.
Gene name:  BAG1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 104 4
GENE REF ISO

Function

 show evidences
Overview 
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.  
3
  • CuratedUniProtKB
GO molecular function 
Chaperone bindingdefinition[GO:0051087] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Receptor signaling protein activitydefinition[GO:0005057]  
1
  • TASPINC
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Chaperone cofactor-dependent protein refoldingdefinition[GO:0070389]  
1
  • IDAUniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • TASGOC
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+573  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BAG1
GenomeRNAi: 573
PRO: PR:Q99933