ATF6B - Cyclic AMP-dependent transcription factor ATF-6 beta - human protein (Function)
 
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ATF6B »  Cyclic AMP-dependent transcription factor ATF-6 beta  (cAMP-dependent transcription factor ATF-6 beta)
 
Protein also known as:  cAMP response element-binding protein-related protein (Creb-rp). Cleaved into:  Processed cyclic AMP-dependent transcription factor ATF-6 beta.
Gene name:  ATF6B
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 17 2
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.  
1
  • UniProtKB
GO molecular function 
cAMP response element bindingdefinition[GO:0035497] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
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  • IntAct
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • ParkinsonsUK-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • ParkinsonsUK-UCL
GO biological process 
ATF6-mediated unfolded protein responsedefinition[GO:0036500]  
1
  • ParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressdefinition[GO:1990440]  
2
  • ParkinsonsUK-UCL
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+1388  
Protein processing in endoplasmic reticulum  hsa04141+1388  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CREBL1
GenomeRNAi: 1388
PRO: PR:Q99941