AGPAT1 - 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha - human protein (Function)
 
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AGPAT1 »  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha   [ EC 2.3.1.51 ]
 
Protein also known as:  1-acylglycerol-3-phosphate O-acyltransferase 1 (1-AGPAT 1).
Gene name:  AGPAT1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.  
1
  • CuratedUniProtKB
GO molecular function 
1-acylglycerol-3-phosphate O-acyltransferase activitydefinition[GO:0003841]  
1
  • IGIBHF-UCL
GO biological process 
CDP-diacylglycerol biosynthetic processdefinition[GO:0016024]  
  • IEAUniPathway
Phosphatidic acid biosynthetic processdefinition[GO:0006654]  
1
  • IGIBHF-UCL
Positive regulation of cytokine productiondefinition[GO:0001819]  
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  • IMPBHF-UCL
Positive regulation of cytokine-mediated signaling pathwaydefinition[GO:0001961]  
1
  • ICBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.51: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fat digestion and absorption  hsa04975+10554  
Glycerolipid metabolism  hsa00561+10554  
Glycerophospholipid metabolism  hsa00564+10554  
Metabolic pathways  hsa01100+10554  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AGPAT1
GenomeRNAi: 10554
PRO: PR:Q99943