PKP2 - Plakophilin-2 - human protein (Function)
 
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Protein
Gene
References

 
PKP2 »  Plakophilin-2
 
Gene name:  PKP2
Family name: Beta-catenin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 83 2
GENE REF ISO

Function

 show evidences
Overview 
May play a role in junctional plaques.  
2
  • UniProtKB
GO molecular function 
Alpha-catenin bindingdefinition[GO:0045294]  
1
  • BHF-UCL
Cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communicationdefinition[GO:0086083]  
1
  • BHF-UCL
Intermediate filament bindingdefinition[GO:0019215]  
1
  • BHF-UCL
Ion channel bindingdefinition[GO:0044325]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • BHF-UCL
Protein complex scaffolddefinition[GO:0032947]  
1
  • BHF-UCL
Protein kinase C bindingdefinition[GO:0005080]  
1
  • BHF-UCL
Sodium channel regulator activitydefinition[GO:0017080]  
1
  • Ortholog Curator
GO biological process 
Adherens junction maintenancedefinition[GO:0034334]  
1
  • Ortholog Curator
Bundle of His cell-Purkinje myocyte adhesion involved in cell communicationdefinition[GO:0086073]  
1
  • BHF-UCL
Cardiac muscle cell action potentialdefinition[GO:0086001]  
1
  • Ortholog Curator
Cardiac muscle cell action potential involved in contractiondefinition[GO:0086002]  
1
  • BHF-UCL
Cell communication by electrical coupling involved in cardiac conductiondefinition[GO:0086064]  
1
  • Ortholog Curator
Cell-cell signaling involved in cardiac conductiondefinition[GO:0086019]  
1
  • BHF-UCL
Desmosome assemblydefinition[GO:0002159]  
1
  • BHF-UCL
Establishment of protein localization to plasma membranedefinition[GO:0090002]  
1
  • BHF-UCL
Gap junction assemblydefinition[GO:0016264]  
1
  • Ortholog Curator
Heart developmentdefinition[GO:0007507]  
1
  • Ortholog Curator
Intermediate filament bundle assemblydefinition[GO:0045110]  
1
  • BHF-UCL
Lipid homeostasisdefinition[GO:0055088]  
1
  • Ortholog Curator
Maintenance of organ identitydefinition[GO:0048496]  
1
  • BHF-UCL
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • Ortholog Curator
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • Ortholog Curator
Positive regulation of sodium ion transportdefinition[GO:0010765]  
1
  • Ortholog Curator
Regulation of bicellular tight junction assemblydefinition[GO:2000810]  
1
  • Ortholog Curator
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
2
  • BHF-UCL
Regulation of ventricular cardiac muscle cell action potentialdefinition[GO:0098911]  
1
  • BHF-UCL
Single organismal cell-cell adhesiondefinition[GO:0016337]  
2
  • UniProtKB
  • Ortholog Curator
Ventricular cardiac muscle cell action potentialdefinition[GO:0086005]  
1
  • BHF-UCL
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
1
  • BHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+5318  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PKP2
GenomeRNAi: 5318
PRO: PR:Q99959