ADAM2 - Disintegrin and metalloproteinase domain-containing protein 2 - human protein (Function)
 
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ADAM2 »  Disintegrin and metalloproteinase domain-containing protein 2  (ADAM 2)
 
Protein also known as:  Cancer/testis antigen 15 (CT15).
Gene name:  ADAM2
Entry whose protein(s) existence is based on evidence at protein level
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1 26 2
GENE REF ISO

Function

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Overview 
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.  
  • CuratedUniProtKB
GO molecular function 
Integrin bindingdefinition[GO:0005178]  
1
  • TASPINC
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Metallopeptidase activitydefinition[GO:0008237]  
1
  • TASPINC
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Adult behaviordefinition[GO:0030534] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155] silver  
  • IEAOrtholog Compara
Fusion of sperm to egg plasma membranedefinition[GO:0007342]  
1
  • TASPINC
Proteolysisdefinition[GO:0006508] silver  
  • IEAInterPro 2 GO
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Interaction With The Zona Pellucida  REACT_163933  
Note 
In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAM2
GenomeRNAi: 2515
PRO: PR:Q99965