AKAP9 - A-kinase anchor protein 9 - human protein (Function)
 
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AKAP9 »  A-kinase anchor protein 9  (AKAP-9)
 
Protein also known as:  Centrosome- and Golgi-localized PKN-associated protein (CG-NAP).
Gene name:  AKAP9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus.  
1
  • CuratedUniProtKB
Isoform  Iso 4   Is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations.  
1
  • CuratedUniProtKB
GO molecular function 
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Protein complex scaffolddefinition[GO:0032947]  
1
  • IDABHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • TASPINC
GO biological process 
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
CREB phosphorylation through the activation of CaMKII  REACT_20642  
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
Ras activation uopn Ca2+ infux through NMDA receptor  REACT_20546  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
Unblocking of NMDA receptor, glutamate binding and activation  REACT_20594  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AKAP9
GenomeRNAi: 10142
PRO: PR:Q99996