AKAP9 - A-kinase anchor protein 9 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
AKAP9 »  A-kinase anchor protein 9  (AKAP-9)
 
Protein also known as:  Centrosome- and Golgi-localized PKN-associated protein (CG-NAP).
Gene name:  AKAP9
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 92 6
GENE REF ISO

Function

 show evidences
Overview 
Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed10202149, PubMed15047863). Recruited to the Golgi apparatus by GM130/GOLGA2 and is required for microtubule nucleation at the cis-side of the Golgi apparatusGM130/GOLGA2.  
4
  • UniProtKB
Isoform  Iso 4   Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations.  
2
  • UniProtKB
GO molecular function 
Ion channel bindingdefinition[GO:0044325]  
3
  • BHF-UCL
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
Protein complex scaffolddefinition[GO:0032947]  
1
  • BHF-UCL
Protein kinase A regulatory subunit bindingdefinition[GO:0034237]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • PINC
GO biological process 
Cellular response to cAMPdefinition[GO:0071320]  
2
  • BHF-UCL
Microtubule nucleationdefinition[GO:0007020]  
1
  • UniProtKB
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • BHF-UCL
Positive regulation of potassium ion transmembrane transporter activitydefinition[GO:1901018]  
1
  • BHF-UCL
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
1
  • BHF-UCL
Regulation of membrane repolarizationdefinition[GO:0060306]  
1
  • BHF-UCL
Regulation of ventricular cardiac muscle cell membrane repolarizationdefinition[GO:0060307]  
1
  • BHF-UCL
Sertoli cell developmentdefinition[GO:0060009] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Anchoring of the basal body to the plasma membrane  R-HSA-5620912  
CREB phosphorylation through the activation of CaMKII  R-HSA-442729  
Loss of Nlp from mitotic centrosomes  R-HSA-380259  
RAF/MAP kinase cascade  R-HSA-5673001  
Ras activation uopn Ca2+ infux through NMDA receptor  R-HSA-442982  
Recruitment of mitotic centrosome proteins and complexes  R-HSA-380270  
Regulation of PLK1 Activity at G2/M Transition  R-HSA-2565942  
Unblocking of NMDA receptor, glutamate binding and activation  R-HSA-438066  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AKAP9
GenomeRNAi: 10142
PRO: PR:Q99996