P2RY13 - P2Y purinoceptor 13 - human protein (Function)
 
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Protein
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References

 
P2RY13 »  P2Y purinoceptor 13  (P2Y13)
 
Protein also known as:  G-protein coupled receptor 94.
Gene name:  P2RY13
Entry whose protein(s) existence is based on evidence at transcript level
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1 17 2
GENE REF ISO

Function

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Overview 
Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.  
1
  • CuratedUniProtKB
GO molecular function 
G-protein coupled purinergic nucleotide receptor activitydefinition[GO:0045028] silver  
  • IEAOrtholog Compara
GO biological process 
Negative regulation of adenylate cyclase activitydefinition[GO:0007194] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+53829  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Note 
Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: P2RY13
GenomeRNAi: 53829
PRO: PR:Q9BPV8
Chemistry
GuidetoPHARMACOLOGY: 329