HOPX - Homeodomain-only protein - human protein (Function)
 
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HOPX »  Homeodomain-only protein
 
Protein also known as:  Not expressed in choriocarcinoma protein 1.
Gene name:  HOPX
Entry whose protein(s) existence is based on evidence at protein level
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1 32 4
GENE REF ISO

Function

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Overview 
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.  
  • CuratedUniProtKB
GO molecular function 
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Histone deacetylationdefinition[GO:0016575] silver  
  • IEAOrtholog Compara
Lung alveolus developmentdefinition[GO:0048286] silver  
  • IEAOrtholog Compara
Negative regulation of cell differentiationdefinition[GO:0045596]  
1
  • IDAMGI
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Positive regulation of skeletal muscle tissue regenerationdefinition[GO:0043415] silver  
  • IEAOrtholog Compara
Positive regulation of striated muscle cell differentiationdefinition[GO:0051155] silver  
  • IEAOrtholog Compara
Regulation of heart contractiondefinition[GO:0008016] silver  
  • IEAOrtholog Compara
Regulation of protein bindingdefinition[GO:0043393] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Trophectodermal cell differentiationdefinition[GO:0001829]  
1
  • IDAMGI
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HOPX
GenomeRNAi: 84525
PRO: PR:Q9BPY8