KCNS3 - Potassium voltage-gated channel subfamily S member 3 - human protein (Function)
 
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Protein
Gene
References

 
KCNS3 »  Potassium voltage-gated channel subfamily S member 3
 
Protein also known as:  Delayed-rectifier K(+) channel alpha subunit 3.
Gene name:  KCNS3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.2.15  
GO molecular function 
Delayed rectifier potassium channel activitydefinition[GO:0005251]  
1
  • PINC
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • PINC
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Protein homooligomerizationdefinition[GO:0051260] silver  
1
  • InterPro 2 GO
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  R-HSA-381676  
Voltage gated Potassium channels  R-HSA-1296072  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNS3
GenomeRNAi: 3790
PRO: PR:Q9BQ31