PDCD1LG2 - Programmed cell death 1 ligand 2 - human protein (Function)
 
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PDCD1LG2 »  Programmed cell death 1 ligand 2  (PD-L2)
 
Protein also known as:  Butyrophilin B7-DC (B7-DC); CD antigen CD273.
Gene name:  PDCD1LG2
Family name: Immunoglobulin » BTN/MOG
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).  
1
  • UniProtKB
GO biological process 
Immune responsedefinition[GO:0006955]  
1
  • UniProtKB
Negative regulation of activated T cell proliferationdefinition[GO:0046007]  
1
  • UniProtKB
Negative regulation of interferon-gamma productiondefinition[GO:0032689]  
1
  • UniProtKB
Negative regulation of interleukin-10 productiondefinition[GO:0032693]  
1
  • UniProtKB
Positive regulation of T cell proliferationdefinition[GO:0042102] silver  
1
  • Ortholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cell adhesion molecules (CAMs)  hsa04514+80380  
According to Reactome, this protein belongs to the following pathway:
PD-1 signaling  REACT_19324  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PDCD1LG2
GenomeRNAi: 80380
PRO: PR:Q9BQ51