TUBA1C - Tubulin alpha-1C chain - human protein (Function)
 
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TUBA1C »  Tubulin alpha-1C chain
 
Protein also known as:  Tubulin alpha-6 chain.
Gene name:  TUBA1C
Family name: Tubulin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.  
  • CuratedUniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200] silver  
  • IEAInterPro 2 GO
Structural molecule activitydefinition[GO:0005198]  
1
  • TASBHF-UCL
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • TASBHF-UCL
Cytoskeleton-dependent intracellular transportdefinition[GO:0030705]  
1
  • TASBHF-UCL
GTP catabolic processdefinition[GO:0006184] silver  
  • IEAInterPro 2 GO
Microtubule-based processdefinition[GO:0007017]  
1
  • TASBHF-UCL
Protein polymerizationdefinition[GO:0051258] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+84790  
Pathogenic Escherichia coli infection  hsa05130+84790  
Phagosome  hsa04145+84790  
According to Reactome, this protein belongs to the following pathways:
Formation of tubulin folding intermediates by CCT/TriC  REACT_16956  
Gap junction assembly  REACT_9509  
Kinesins  REACT_25201  
MHC class II antigen presentation  REACT_121399  
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane  REACT_11039  
Mitotic Prometaphase  REACT_682  
Post-chaperonin tubulin folding pathway  REACT_16967  
Prefoldin mediated transfer of substrate to CCT/TriC  REACT_16936  
Recruitment of NuMA to mitotic centrosomes  REACT_15510  
Recycling pathway of L1  REACT_22365  
Resolution of Sister Chromatid Cohesion  REACT_150425  
Separation of Sister Chromatids  REACT_150471  
Translocation of GLUT4 to the plasma membrane  REACT_147867  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TUBA1C
GenomeRNAi: 84790
PRO: PR:Q9BQE3