VIMP - Selenoprotein S - human protein (Function)
 
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VIMP »  Selenoprotein S  (SelS)
 
Protein also known as:  VCP-interacting membrane protein.
Gene name:  VIMP
Family name: Selenoprotein S
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.  
1
  • CuratedUniProtKB
GO molecular function 
Antioxidant activitydefinition[GO:0016209]  
1
  • IDAUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • NASUniProtKB
Selenium bindingdefinition[GO:0008430] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell redox homeostasisdefinition[GO:0045454]  
1
  • IDAUniProtKB
Cellular response to insulin stimulusdefinition[GO:0032869]  
1
  • TASBHF-UCL
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • IMPBHF-UCL
Cellular response to oxidative stressdefinition[GO:0034599]  
1
  • IMPBHF-UCL
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
1
  • IDAUniProtKB
ER overload responsedefinition[GO:0006983]  
2
  • IMPBHF-UCL
ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:0030433]  
1
  • IDAUniProtKB
Establishment of protein localizationdefinition[GO:0045184]  
1
  • TASUniProtKB
Negative regulation of acute inflammatory response to antigenic stimulusdefinition[GO:0002865]  
1
  • IMPBHF-UCL
Negative regulation of glucose importdefinition[GO:0046325]  
1
  • TASBHF-UCL
Negative regulation of glycogen biosynthetic processdefinition[GO:0045719]  
1
  • TASBHF-UCL
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • ICBHF-UCL
Negative regulation of interleukin-6 productiondefinition[GO:0032715]  
  • ISSOrtholog Curator
Negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:1902236]  
1
  • IMPBHF-UCL
Negative regulation of macrophage apoptotic processdefinition[GO:2000110]  
1
  • IMPBHF-UCL
Negative regulation of nitric-oxide synthase biosynthetic processdefinition[GO:0051771]  
1
  • IMPBHF-UCL
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
  • ISSOrtholog Curator
Regulation of gluconeogenesisdefinition[GO:0006111]  
1
  • TASBHF-UCL
Regulation of nitric oxide metabolic processdefinition[GO:0080164]  
1
  • IMPBHF-UCL
Response to glucosedefinition[GO:0009749]  
2
  • IEPUniProtKB
  • IEPBHF-UCL
Response to redox statedefinition[GO:0051775]  
1
  • IDAUniProtKB
Retrograde protein transport, ER to cytosoldefinition[GO:0030970]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+55829  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SELS_(gene)
GenomeRNAi: 55829
PRO: PR:Q9BQE4