JPH2 - Junctophilin-2 - human protein (Function)
 
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JPH2 »  Junctophilin-2  (JP-2)
 
Protein also known as:  Junctophilin type 2.
Gene name:  JPH2
Family name: Junctophilin
Entry whose protein(s) existence is based on evidence at protein level
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1 32 2
GENE REF ISO

Function

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Overview 
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.  
2
  • UniProtKB
GO molecular function 
Calcium-release channel activitydefinition[GO:0015278]  
1
  • UniProtKB
Phosphatidic acid bindingdefinition[GO:0070300]  
1
  • UniProtKB
Phosphatidylinositol-3,4,5-trisphosphate bindingdefinition[GO:0005547]  
1
  • UniProtKB
Phosphatidylinositol-3,5-bisphosphate bindingdefinition[GO:0080025]  
1
  • UniProtKB
Phosphatidylinositol-3-phosphate bindingdefinition[GO:0032266]  
1
  • UniProtKB
Phosphatidylinositol-4,5-bisphosphate bindingdefinition[GO:0005546]  
1
  • UniProtKB
Phosphatidylinositol-4-phosphate bindingdefinition[GO:0070273]  
1
  • UniProtKB
Phosphatidylinositol-5-phosphate bindingdefinition[GO:0010314]  
1
  • UniProtKB
Phosphatidylserine bindingdefinition[GO:0001786]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
GO biological process 
Calcium ion homeostasisdefinition[GO:0055074]  
1
  • UniProtKB
Calcium ion transmembrane transportdefinition[GO:0070588] silver  
1
  • Ortholog Compara
Calcium ion transport into cytosoldefinition[GO:0060402]  
1
  • BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060316]  
1
  • UniProtKB
Regulation of cardiac muscle tissue developmentdefinition[GO:0055024] silver  
1
  • Ortholog Compara
Regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060314]  
1
  • BHF-UCL
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: JPH2
GenomeRNAi: 57158
PRO: PR:Q9BR39