JPH2 - Junctophilin-2 - human protein (Function)
 
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JPH2 »  Junctophilin-2  (JP-2)
 
Protein also known as:  Junctophilin type 2.
Gene name:  JPH2
Family name: Junctophilin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium-release channel activitydefinition[GO:0015278]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Calcium ion homeostasisdefinition[GO:0055074]  
1
  • IDAUniProtKB
Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • IDAGOC
Calcium ion transport into cytosoldefinition[GO:0060402]  
1
  • TASBHF-UCL
Ion transmembrane transportdefinition[GO:0034220]  
1
  • IDAGOC
Positive regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060316]  
1
  • IDAUniProtKB
Regulation of cardiac muscle tissue developmentdefinition[GO:0055024] silver  
  • IEAOrtholog Compara
Regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060314]  
1
  • TASBHF-UCL
Transmembrane transportdefinition[GO:0055085]  
1
  • IDAGOC
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: JPH2
GenomeRNAi: 57158
PRO: PR:Q9BR39