ERP44 - Endoplasmic reticulum resident protein 44 - human protein (Function)
 
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ERP44 »  Endoplasmic reticulum resident protein 44  (ERp44)
 
Protein also known as:  Thioredoxin domain-containing protein 4.
Gene name:  ERP44
Entry whose protein(s) existence is based on evidence at protein level
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1 31 1
GENE REF ISO

Function

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Overview 
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein disulfide isomerase activitydefinition[GO:0003756]  
1
  • IDAUniProtKB
GO biological process 
Cell redox homeostasisdefinition[GO:0045454]  
1
  • TASUniProtKB
Glycoprotein metabolic processdefinition[GO:0009100]  
1
  • IDAUniProtKB
Protein foldingdefinition[GO:0006457]  
1
  • IDAUniProtKB
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • IDAUniProtKB
Response to unfolded proteindefinition[GO:0006986]  
1
  • IDAUniProtKB
 

Keywords

Biological process 
Stress response  definition   [KW-0346]
Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ERP44
GenomeRNAi: 23071
PRO: PR:Q9BS26