ALKBH7 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial - human protein (Function)
 
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ALKBH7 »  Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial   [ EC 1.14.11.- ]
 
Protein also known as:  Spermatogenesis cell proliferation-related protein.
Gene name:  ALKBH7
Family name: AlkB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probable dioxygenase required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.  
1
  • CuratedUniProtKB
GO molecular function 
Dioxygenase activitydefinition[GO:0051213]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDAUniProtKB
Fatty acid metabolic processdefinition[GO:0006631]  
  • ISSOrtholog Curator
Necrotic cell deathdefinition[GO:0070265]  
1
  • IMPUniProtKB
Programmed cell deathdefinition[GO:0012501]  
  • IEAUniProtKB KW
Regulation of lipid storagedefinition[GO:0010883]  
  • ISSOrtholog Curator
Enzymatic activity 
It requires the following cofactor
Binds 1 Fe(2+) ion per subunit (By similarity).  
  • CuratedUniProtKB
Caution 
Was initially reported to localize both in cytoplasm and nucleus (PubMed17979886). However, it was later shown it localizes in mitochondrion (PubMed23666923). The discrepancy is probably due to the use of a fusion protein with an N-terminal tag in the initial report (PubMed17979886).  
2
  • CuratedUniProtKB
 

Keywords

Biological process 
Necrosis  definition   [KW-1210]
Molecular function 
Dioxygenase  definition   [KW-0223]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84266
PRO: PR:Q9BT30