ALKBH7 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial - human protein (Function)
 
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ALKBH7 »  Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial   [ EC 1.14.11.- ]
 
Protein also known as:  Spermatogenesis cell proliferation-related protein.
Gene name:  ALKBH7
Family name: AlkB
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed23666923). Does not display DNA demethylase activity (PubMed23666923). Involved in fatty acid metabolism (By similarity).  
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  • UniProtKB
GO molecular function 
Dioxygenase activitydefinition[GO:0051213]  
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Metal ion bindingdefinition[GO:0046872]  
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GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
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Fatty acid metabolic processdefinition[GO:0006631]  
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  • Ortholog Curator
Oxidation-reduction processdefinition[GO:0055114]  
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  • UniProtKB KW
Regulation of lipid storagedefinition[GO:0010883]  
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  • Ortholog Curator
Regulation of mitochondrial membrane permeability involved in programmed necrotic cell deathdefinition[GO:1902445]  
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Enzymatic activity 
It requires the following cofactor
 Fe(2+) : Binds 1 Fe(2+) ion per subunit.  
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Caution 
Was initially reported to localize both in cytoplasm and nucleus (PubMed17979886). However, it was later shown it localizes in mitochondrion (PubMed23666923). The discrepancy is probably due to the use of a fusion protein with an N-terminal tag in the initial report (PubMed17979886).  
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  • UniProtKB
 

Keywords

Biological process 
Necrosis  definition   [KW-1210]
Molecular function 
Dioxygenase  definition   [KW-0223]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84266
PRO: PR:Q9BT30