SPX - Spexin - human protein (Function)
 
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Protein
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SPX »  Spexin
 
Protein also known as:  Neuropeptide Q. Cleaved into:  Spexin-1; Spexin-2.
Gene name:  SPX
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity).  
  • CuratedUniProtKB
Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed17284679, PubMed24517231).  
2
  • CuratedUniProtKB
Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Neuropeptide hormone activitydefinition[GO:0005184]  
1
  • IDAUniProtKB
Type 2 galanin receptor bindingdefinition[GO:0031765]  
1
  • IDAUniProtKB
Type 3 galanin receptor bindingdefinition[GO:0031766]  
1
  • IDAUniProtKB
GO biological process 
Long-chain fatty acid importdefinition[GO:0044539]  
  • ISSOrtholog Curator
Negative regulation of appetitedefinition[GO:0032099]  
  • ISSOrtholog Curator
Negative regulation of heart ratedefinition[GO:0010459]  
  • ISSOrtholog Curator
Negative regulation of renal sodium excretiondefinition[GO:0035814]  
  • ISSOrtholog Curator
Positive regulation of systemic arterial blood pressuredefinition[GO:0003084]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Regulation of sensory perception of paindefinition[GO:0051930]  
  • ISSOrtholog Curator
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 80763