CHRDL1 - Chordin-like protein 1 - human protein (Function)
 
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Protein
Gene
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CHRDL1 »  Chordin-like protein 1
 
Protein also known as:  Neurogenesin-1.
Gene name:  CHRDL1
Entry whose protein(s) existence is based on evidence at protein level
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1 21 6
GENE REF ISO

Function

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Overview 
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.  
3
  • UniProtKB
GO biological process 
Compound eye developmentdefinition[GO:0048749]  
1
  • UniProtKB
Eye developmentdefinition[GO:0001654]  
1
  • UniProtKB
Negative regulation of BMP signaling pathwaydefinition[GO:0030514] silver  
1
  • Ortholog Compara
Neuron differentiationdefinition[GO:0030182] silver  
1
  • InterPro 2 GO
Ossificationdefinition[GO:0001503]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signaling by BMP  REACT_12034  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Osteogenesis  definition   [KW-0892]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 91851
PRO: PR:Q9BU40