MKNK1 - MAP kinase-interacting serine/threonine-protein kinase 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MKNK1 »  MAP kinase-interacting serine/threonine-protein kinase 1
 
Gene name:  MKNK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 3
GENE REF ISO

Function

 show evidences
Overview 
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDABHF-UCL
  • IDAUniProtKB
GO biological process 
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAUniProtKB
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • IDABHF-UCL
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of translationdefinition[GO:0006417]  
  • IEAUniProtKB KW
Response to salt stressdefinition[GO:0009651] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
2
  • CuratedUniProtKB
It is regulated in the following manner
Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Insulin signaling pathway  hsa04910+8569  
MAPK signaling pathway  hsa04010+8569  
According to Reactome, this protein belongs to the following pathway:
Spry regulation of FGF signaling  REACT_111080  
 

Keywords

Biological process 
Translation regulation  definition   [KW-0810]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MKNK1
GenomeRNAi: 8569
PRO: PR:Q9BUB5
Chemistry
GuidetoPHARMACOLOGY: 2104