MKNK1 - MAP kinase-interacting serine/threonine-protein kinase 1 - human protein (Function)
 
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MKNK1 »  MAP kinase-interacting serine/threonine-protein kinase 1   [ EC 2.7.11.1 ]
 
Protein also known as:  MAP kinase signal-integrating kinase 1 (Mnk1).
Gene name:  MKNK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 3
GENE REF ISO

Function

 show evidences
Overview 
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.  
5
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
Calcium-dependent protein serine/threonine kinase activitydefinition[GO:0009931]  
1
  • RefGenome
Calmodulin bindingdefinition[GO:0005516]  
1
  • RefGenome
Calmodulin-dependent protein kinase activitydefinition[GO:0004683]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • BHF-UCL
  • UniProtKB
GO biological process 
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
1
  • Ortholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • UniProtKB
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • BHF-UCL
Protein autophosphorylationdefinition[GO:0046777]  
1
  • RefGenome
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of translational initiationdefinition[GO:0006446] silver  
1
  • Ortholog Compara
Response to salt stressdefinition[GO:0009651] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
3
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
3
  • UniProtKB
It is regulated in the following manner
Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Insulin signaling pathway  hsa04910+8569  
MAPK signaling pathway  hsa04010+8569  
According to Reactome, this protein belongs to the following pathway:
Spry regulation of FGF signaling  REACT_111080  
 

Keywords

Biological process 
Translation regulation  definition   [KW-0810]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MKNK1
GenomeRNAi: 8569
PRO: PR:Q9BUB5
Chemistry
GuidetoPHARMACOLOGY: 2104