G6PC3 - Glucose-6-phosphatase 3 - human protein (Function)
 
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Protein
Gene
References

 
G6PC3 »  Glucose-6-phosphatase 3   [ EC 3.1.3.9 ]  (G6Pase 3)
 
Protein also known as:  Ubiquitous glucose-6-phosphatase catalytic subunit-related protein.
Gene name:  G6PC3
Family name: Glucose-6-phosphatase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.  
3
  • CuratedUniProtKB
GO molecular function 
Glucose-6-phosphatase activitydefinition[GO:0004346]  
  • IEAEC 2 GO
GO biological process 
Gluconeogenesisdefinition[GO:0006094]  
  • IEAUniPathway
Glucose 6-phosphate metabolic processdefinition[GO:0051156] silver  
  • IEAOrtholog Compara
Glucose-6-phosphate transportdefinition[GO:0015760] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.9: D-glucose 6-phosphate + H(2)O D-glucose + phosphate.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by vanadate.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
Caution 
According to PubMed12370122, it has no hydrolytic activity.  
1
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
8 times less active compared to G6PC under the same experimental conditions.
KM 2.0 mM for glucose-6-phosphate (at pH 6.5)
KM 1.0 mM for glucose-6-phosphate (at pH 5.5)

Keywords

Biological process 
Gluconeogenesis  definition   [KW-0312]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9BUM1
Other
GeneWiki: G6PC3
GenomeRNAi: 92579
PRO: PR:Q9BUM1