APOO - MICOS complex subunit MIC26 - human protein (Function)
 
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APOO »  MICOS complex subunit MIC26
 
Protein also known as:  MICOS complex subunit MIC23.
Gene name:  APOO
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed16956892).  
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  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • UniProtKB
GO biological process 
Cristae formationdefinition[GO:0042407]  
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  • UniProtKB
Lipid transportdefinition[GO:0006869]  
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  • UniProtKB KW
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_O
GenomeRNAi: 79135
PRO: PR:Q9BUR5