ALG12 - Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase - human protein (Function)
 
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Protein
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ALG12 »  Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase   [ EC 2.4.1.260 ]
 
Protein also known as:  Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase.
Gene name:  ALG12
Family name: Glycosyltransferase 22
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 22 1
GENE REF ISO

Function

 show evidences
Overview 
Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.  
  • CuratedUniProtKB
GO molecular function 
Alpha-1,6-mannosyltransferase activitydefinition[GO:0000009]  
1
  • ICUniProtKB
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activitydefinition[GO:0052917]  
  • IEAEC 2 GO
GO biological process 
Dolichol-linked oligosaccharide biosynthetic processdefinition[GO:0006488]  
1
  • IDAMGI
Mannosylationdefinition[GO:0097502]  
1
  • ICGOC
Protein foldingdefinition[GO:0006457]  
1
  • NASUniProtKB
Protein N-linked glycosylationdefinition[GO:0006487]  
1
  • IGIUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.260: Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 22  GT22  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+79087  
N-Glycan biosynthesis  hsa00510+79087  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALG12
GenomeRNAi: 79087
PRO: PR:Q9BV10