MRI1 - Methylthioribose-1-phosphate isomerase - human protein (Function)
 
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MRI1 »  Methylthioribose-1-phosphate isomerase   [ EC 5.3.1.23 ]  (M1Pi)
 
Protein also known as:  Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
Gene name:  MRI1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.  
3
  • UniProtKB
  • HAMAP-Rule
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
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  • IntAct
S-methyl-5-thioribose-1-phosphate isomerase activitydefinition[GO:0046523]  
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  • RefGenome
GO biological process 
L-methionine biosynthetic process from methylthioadenosinedefinition[GO:0019509]  
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  • UniPathway
  • RefGenome
L-methionine biosynthetic process from S-adenosylmethioninedefinition[GO:0019284]  
1
  • UniProtKB Annot
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.1.23: S-methyl-5-thio-alpha-D-ribose 1-phosphate S-methyl-5-thio-D-ribulose 1-phosphate.  
2
  • UniProtKB
  • HAMAP-Rule
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6  
2
  • HAMAP-Rule
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+84245  
Metabolic pathways  hsa01100+84245  
According to Reactome, this protein belongs to the following pathway:
Methionine salvage pathway  REACT_75881  
 

Keywords

Biological process 
Amino-acid biosynthesis  definition   [KW-0028]
Methionine biosynthesis  definition   [KW-0486]
Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MGC3207
GenomeRNAi: 84245
PRO: PR:Q9BV20