ABHD6 - Monoacylglycerol lipase ABHD6 - human protein (Function)
 
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Protein
Gene
References

 
ABHD6 »  Monoacylglycerol lipase ABHD6   [ EC 3.1.1.23 ]
 
Protein also known as:  Abhydrolase domain-containing protein 6.
Gene name:  ABHD6
Family name: AB hydrolase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).  
3
  • UniProtKB
GO molecular function 
Acylglycerol lipase activitydefinition[GO:0047372]  
1
  • UniProtKB
GO biological process 
Acylglycerol catabolic processdefinition[GO:0046464]  
1
  • UniProtKB
Long term synaptic depressiondefinition[GO:0060292] silver  
1
  • Ortholog Compara
Negative regulation of cell migrationdefinition[GO:0030336] silver  
1
  • Ortholog Compara
Regulation of endocannabinoid signaling pathwaydefinition[GO:2000124] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.1.23: Hydrolyzes glycerol monoesters of long-chain fatty acids.  
2
  • UniProtKB
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 159 uM for 2-arachidonoyglycerol
Vmax 45 nmol/min/mg enzyme toward 2-arachidonoyglycerol
Dependence
pH Optimum pH is 7.2-9 with 2-arachidonoyglycerol as substrate.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 57406
PRO: PR:Q9BV23