PHF20 - PHD finger protein 20 - human protein (Function)
 
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Protein
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PHF20 »  PHD finger protein 20
 
Protein also known as:  Hepatocellular carcinoma-associated antigen 58.
Gene name:  PHF20
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 42 2
GENE REF ISO

Function

 show evidences
Overview 
Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.  
2
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Contributes to histone acetyltransferase activity (H4-K16 specific)definition[GO:0046972]  
1
  • IDAUniProtKB
Contributes to histone acetyltransferase activity (H4-K5 specific)definition[GO:0043995]  
1
  • IDAUniProtKB
Contributes to histone acetyltransferase activity (H4-K8 specific)definition[GO:0043996]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Histone H4-K16 acetylationdefinition[GO:0043984]  
1
  • IDAUniProtKB
Histone H4-K5 acetylationdefinition[GO:0043981]  
1
  • IDAUniProtKB
Histone H4-K8 acetylationdefinition[GO:0043982]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
HATs acetylate histones  REACT_172610  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PHF20
GenomeRNAi: 51230
PRO: PR:Q9BVI0