ALG8 - Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase - human protein (Function)
 
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Protein
Gene
References

 
ALG8 »  Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase   [ EC 2.4.1.265 ]
 
Protein also known as:  Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase.
Gene name:  ALG8
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 18 2
GENE REF ISO

Function

 show evidences
Overview 
Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Alpha-1,3-mannosyltransferase activitydefinition[GO:0000033]  
1
  • IMPUniProtKB
GO biological process 
Mannosylationdefinition[GO:0097502]  
1
  • IMPGOC
Protein N-linked glycosylationdefinition[GO:0006487]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.265: Dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 57  GT57  
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+79053  
N-Glycan biosynthesis  hsa00510+79053  
According to Reactome, this protein belongs to the following pathway:
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein  REACT_22433  
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALG8
GenomeRNAi: 79053
PRO: PR:Q9BVK2