GGACT - Gamma-glutamylaminecyclotransferase - human protein (Function)
 
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Protein
Gene
References

 
GGACT »  Gamma-glutamylaminecyclotransferase   [ EC 2.3.2.4 ]  (GGACT)
 
Protein also known as:  AIG2-like domain-containing protein 1.
Gene name:  GGACT
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Contributes to degradation of proteins cross-linked by transglutaminases. Degrades the cross-link between a lysine and a glutamic acid residue from two proteins that have been cross-linked by transglutaminases. Catalyzes the formation of 5-oxoproline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.  
2
  • UniProtKB
GO molecular function 
Gamma-glutamylcyclotransferase activitydefinition[GO:0003839]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Cellular modified amino acid catabolic processdefinition[GO:0042219]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.2.4: (Gamma-L-glutamyl)-L-amino acid 5-oxoproline + L-amino acid.  
2
  • UniProtKB
 

Keywords

Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 87769
PRO: PR:Q9BVM4