FAIM2 - Protein lifeguard 2 - human protein (Function)
 
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FAIM2 »  Protein lifeguard 2
 
Protein also known as:  Transmembrane BAX inhibitor motif-containing protein 2.
Gene name:  FAIM2
Family name: BI1 » LFG
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 30 2
GENE REF ISO

Function

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Overview 
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.  
3
  • UniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB KW
Cerebellar granular layer developmentdefinition[GO:0021681]  
1
  • Ortholog Curator
Cerebellar Purkinje cell differentiationdefinition[GO:0021702]  
1
  • Ortholog Curator
Cerebellar Purkinje cell layer developmentdefinition[GO:0021680]  
1
  • Ortholog Curator
Cerebellum developmentdefinition[GO:0021549]  
1
  • Ortholog Curator
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of apoptotic signaling pathwaydefinition[GO:2001234] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Regulation of neuron apoptotic processdefinition[GO:0043523]  
1
  • UniProtKB
Response to ischemiadefinition[GO:0002931] silver  
1
  • Ortholog Compara
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23017
PRO: PR:Q9BWQ8