GATA5 - Transcription factor GATA-5 - human protein (Function)
 
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Gene
References

 
GATA5 »  Transcription factor GATA-5
 
Protein also known as:  GATA-binding factor 5.
Gene name:  GATA5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription factor required during cardiovascular development (PubMed23289003). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed25543888).  
4
  • UniProtKB
GO molecular function 
Enhancer sequence-specific DNA bindingdefinition[GO:0001158] silver  
1
  • Ortholog Compara
Transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingdefinition[GO:0003705] silver  
1
  • Ortholog Compara
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • MGI
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cellular response to BMP stimulusdefinition[GO:0071773] silver  
1
  • Ortholog Compara
Intestinal epithelial cell differentiationdefinition[GO:0060575]  
1
  • MGI
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Factors involved in megakaryocyte development and platelet production  R-HSA-983231  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GATA5
GenomeRNAi: 140628
PRO: PR:Q9BWX5