BRIP1 - Fanconi anemia group J protein - human protein (Function)
 
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BRIP1 »  Fanconi anemia group J protein   [ EC 3.6.4.13 ]  (Protein FACJ)
 
Protein also known as:  BRCA1-interacting protein C-terminal helicase 1 (BRCA1-interacting protein 1).
Gene name:  BRIP1
Family name: DEAD box helicase » DEAH
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 92 2
GENE REF ISO

Function

 show evidences
Overview 
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.  
5
  • UniProtKB
GO molecular function 
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
1
  • UniProtKB KW
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATP-dependent DNA helicase activitydefinition[GO:0004003]  
1
  • UniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
GO biological process 
DNA damage checkpointdefinition[GO:0000077]  
1
  • UniProtKB
DNA duplex unwindingdefinition[GO:0032508]  
2
  • GOC
  • InterPro 2 GO
Double-strand break repairdefinition[GO:0006302]  
1
  • UniProtKB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • MGI
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.13: ATP + H(2)O ADP + phosphate.  
1
  • UniProtKB
It requires the following cofactor
 [4Fe-4S] cluster : Binds 1 [4Fe-4S] cluster.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Fanconi anemia pathway  hsa03460+83990  
According to Reactome, this protein belongs to the following pathways:
Cytosolic iron-sulfur cluster assembly  REACT_160176  
Homologous DNA pairing and strand exchange  REACT_1763  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BRIP1
GenomeRNAi: 83990
PRO: PR:Q9BX63